Document Detail

Effect of sodium nitroprusside on mortality in acute myocardial infarction.
MedLine Citation:
PMID:  7040955     Owner:  NLM     Status:  MEDLINE    
We gave sodium nitroprusside by intravenous infusion to 163 randomly selected patients during the first 24 hours after hospitalization for typical acute myocardial infarction, and we studied its effects on mortality at one week, on the incidence of cardiogenic shock, on clinical signs of left ventricular failure, and on peak levels of creatine kinase isoenzyme MB. A control group of 165 patients received standard medical treatment and infusion of 5 per cent glucose. The end point of the study was a significant reduction in mortality in the nitroprusside group; this was reached when five deaths had occurred in this group, as compared with 18 among the controls (P less than 0.05). The incidence of cardiogenic shock, clinical signs of left-heart failure, and mean peak levels of creatine kinase isoenzyme MB were all reduced (P less than 0.05). The results indicate that infusion of nitroprusside in the early phase of acute infarction limits complications, possibly by reducing infarct size. The drug was particularly effective in anterior-wall infarction.
J D Durrer; K I Lie; F J van Capelle; D Durrer
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The New England journal of medicine     Volume:  306     ISSN:  0028-4793     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  1982 May 
Date Detail:
Created Date:  1982-06-21     Completed Date:  1982-06-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1121-8     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure
Clinical Enzyme Tests
Clinical Trials as Topic
Creatine Kinase / blood
Ferricyanides / therapeutic use*
Infusions, Parenteral
Middle Aged
Myocardial Infarction / classification,  diagnosis,  drug therapy*,  mortality*
Nitroprusside / administration & dosage,  adverse effects,  therapeutic use*
Prospective Studies
Random Allocation
Shock, Cardiogenic / prevention & control
Reg. No./Substance:
0/Ferricyanides; 0/Isoenzymes; 15078-28-1/Nitroprusside; EC Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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