Document Detail


Effect of sodium nitroprusside on cerebral haemodynamics during cross-clamping of the descending thoracic aorta in pigs.
MedLine Citation:
PMID:  8739421     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To assess the effect of sodium nitroprusside on cerebral haemodynamics during cross-clamping of the descending thoracic aorta in pigs. DESIGN: Non-randomised controlled animal study. SETTING: University hospital, Norway. MATERIAL: 17 Pigs. INTERVENTIONS: Cross-clamping of the descending thoracic aorta for 30 minutes. In 8 pigs sodium nitroprusside was given to prevent proximal hypertension (sodium nitroprusside group); 9 pigs were given no sodium nitroprusside (control group). MAIN OUTCOME MEASURES: Intracerebral pressure, sagittal sinus pressure, cerebral flux, and internal carotid artery blood flow. RESULTS: Intracerebral pressure, sagittal sinus pressure, and cerebral flux increased in both groups during cross-clamping of the descending thoracic aorta. There were no differences between the groups in these variables despite significantly lower mean proximal aortic pressure in the sodium nitroprusside group. CONCLUSIONS: Sodium nitroprusside did not affect intracerebral pressure, sagittal sinus pressure, or cerebral flux during cross-clamping of the descending thoracic aorta. Increased cerebral blood flow rather than venous congestion is the most likely cause of increased intracranial pressure during cross-clamping of the descending thoracic aorta.
Authors:
T Strømholm; P Aadahl; O D Saether; S Aakhus; H O Myhre
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The European journal of surgery = Acta chirurgica     Volume:  162     ISSN:  1102-4151     ISO Abbreviation:  Eur J Surg     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-10-09     Completed Date:  1996-10-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9105264     Medline TA:  Eur J Surg     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  329-34     Citation Subset:  IM    
Affiliation:
Department of Surgery, University Hospital of Trondheim, Norway.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Antihypertensive Agents / pharmacology*
Aorta, Thoracic / physiology*
Cerebrovascular Circulation / drug effects*
Constriction
Hypertension / prevention & control
Intracranial Pressure / drug effects*
Nitroprusside / pharmacology*
Time Factors
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 15078-28-1/Nitroprusside

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Postocclusive hyperaemia in skin measured in pigs by laser Doppler: influence of site of arterial st...
Next Document:  Quality of life as a measure of rehabilitation outcome in patients with multiple sclerosis.