Document Detail

Effect of sodium loading and depletion on vascular reactivity and prostacyclin generation.
MedLine Citation:
PMID:  6248654     Owner:  NLM     Status:  MEDLINE    
In order to estimate the modulatory activity of Prostacyclin (PGI2) to the vascular reactivity, pressor responses to angiotensin II (A II) and noradrenaline (NA) and PGI2 generation aorta were measured using the rats of sodium loading or of sodium depletion. On the sodium loading, the blood pressure increased gradually and plasma renin activity (PRA) and plasma aldosterone concentration (PAC) were decreased. The pressor responses to A II and NA were enhanced by sodium loading. The PGI2 generation of aorta was enhanced at the initial stage of sodium loading and decreased thereafter. The increased generation of PGI2 may represent the adaptive mechanism for the attenuation of the sustained elevation in blood pressure. It sodium depletion, the pressor responses to A II and NA were decreased, and PRA and PAC were elevated. PGI2 generation of aorta was also increased. These findings suggested that PGI2 could participate in blood pressure control mechanism on sodium loading and depletion.
M Yoshimura; I Kaimasu; T Kitani; T Kawamura; K Takeda; S Sasaki; Y Kajita; M Nakagawa; H Ijichi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  44     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1980 May 
Date Detail:
Created Date:  1980-09-23     Completed Date:  1980-09-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  388-93     Citation Subset:  IM    
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MeSH Terms
Aldosterone / blood
Angiotensin II / pharmacology
Aorta / metabolism
Blood Pressure / drug effects*
Epoprostenol / biosynthesis*,  physiology
Norepinephrine / pharmacology
Prostaglandins / biosynthesis*
Receptors, Angiotensin / drug effects
Renin / blood
Sodium / pharmacology*
Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors
Reg. No./Substance:
0/Prostaglandins; 0/Receptors, Angiotensin; 11128-99-7/Angiotensin II; 35121-78-9/Epoprostenol; 51-41-2/Norepinephrine; 52-39-1/Aldosterone; 7440-23-5/Sodium; EC; EC ATPase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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