| Effect of sodium houttuyfonate on inhibiting ventricular remodeling induced by abdominal aortic banding in rats. | |
| | |
MedLine Citation:
|
PMID: 20651817 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Ventricular remodeling is an independent risk factor for many cardiovascular events. Inhibiting ventricular remodeling early may be an effective way to postpone heart failure for patients with cardiovascular illness. The study was designed to examine the effect of sodium houttuyfonate on ventricular remodeling induced by pressure overload in rats, as well as to explore the mechanisms involved. The model rats in which ventricular remodeling was induced abdominal aortic banding (AAB) were randomly divided into 4 groups: AAB control, AAB plus captopril (40 mg/kg), AAB plus low dose of sodium houttuyfonate (50 mg/kg), and AAB plus high dose of sodium houttuyfonate (100 mg/kg). One month after operation, hemodynamic parameters, heart mass indexes, size of cardiomyocytes, myocardial collagen volume, angiotensin II content in ventricular tissue, and serum concentrations of aldosterone and tumor necrosis factor (TNF)-alpha were evaluated. Sodium houttuyfonate significantly reduced heart mass indexes, the size of cardiomyocytes, and the myocardial collagen volume and decreased the levels of angiotensin II, aldosterone, and TNF-alpha. At the high dose, it decreased blood pressure and heart rate. In conclusion, sodium houttuyfonate attenuates ventricular remodeling induced by pressure overload in rats. The beneficial effects are in part associated with its alleviating the activation of renin-angiotensin-aldosterone system and decreasing the TNF-alpha level. Furthermore, its function seems to correlate with reduced blood pressure and heart rate. |
| | |
Authors:
|
Jian Ping Gao; Chang Xun Chen; Qi Wu; Wei Liang Gu; Xiang Li |
Related Documents
:
|
3440817 - Effects of hemorrhage and naloxone on adrenal release of methionine-enkephalin and cate... 1269097 - Relation between plasma renin activity, angiotensin, and aldosterone and blood pressure... 7117047 - Circadian variation of aldosterone urinary excretion in idiopathic hypertension. 3323617 - Mechanisms of hypertension in obesity. 12051427 - Energy: converting from acoustic to biological resource units. 3961827 - The italian multicenter study of reversible cerebral ischemic attacks: iv--blood pressu... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Canadian journal of physiology and pharmacology Volume: 88 ISSN: 1205-7541 ISO Abbreviation: Can. J. Physiol. Pharmacol. Publication Date: 2010 Jul |
Date Detail:
|
Created Date: 2010-07-23 Completed Date: 2010-11-05 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372712 Medline TA: Can J Physiol Pharmacol Country: Canada |
Other Details:
|
Languages: eng Pagination: 693-701 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, P.R. China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aldosterone
/
blood Alkanes / pharmacology* Angiotensin II / metabolism Animals Aorta, Abdominal Blood Pressure / drug effects Collagen / metabolism Constriction Heart Failure / prevention & control Male Myocytes, Cardiac / drug effects, pathology Rats Rats, Sprague-Dawley Renin-Angiotensin System / drug effects Sulfites / pharmacology* Tumor Necrosis Factor-alpha / blood Ventricular Function, Left / drug effects Ventricular Remodeling / drug effects*, physiology |
| Chemical | |
Reg. No./Substance:
|
0/Alkanes; 0/Sulfites; 0/Tumor Necrosis Factor-alpha; 0/sodium houttuyfonate; 11128-99-7/Angiotensin II; 52-39-1/Aldosterone; 9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A possible role of myristoylated alanine-rich C kinase substrate in endocytic pathway of Alzheimer's...
Next Document: Involvement of sarcoplasmic reticulum in changing intracellular calcium due to Na+/K+-ATPase inhibit...