Document Detail


Effect of sodium houttuyfonate on inhibiting ventricular remodeling induced by abdominal aortic banding in rats.
MedLine Citation:
PMID:  20651817     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ventricular remodeling is an independent risk factor for many cardiovascular events. Inhibiting ventricular remodeling early may be an effective way to postpone heart failure for patients with cardiovascular illness. The study was designed to examine the effect of sodium houttuyfonate on ventricular remodeling induced by pressure overload in rats, as well as to explore the mechanisms involved. The model rats in which ventricular remodeling was induced abdominal aortic banding (AAB) were randomly divided into 4 groups: AAB control, AAB plus captopril (40 mg/kg), AAB plus low dose of sodium houttuyfonate (50 mg/kg), and AAB plus high dose of sodium houttuyfonate (100 mg/kg). One month after operation, hemodynamic parameters, heart mass indexes, size of cardiomyocytes, myocardial collagen volume, angiotensin II content in ventricular tissue, and serum concentrations of aldosterone and tumor necrosis factor (TNF)-alpha were evaluated. Sodium houttuyfonate significantly reduced heart mass indexes, the size of cardiomyocytes, and the myocardial collagen volume and decreased the levels of angiotensin II, aldosterone, and TNF-alpha. At the high dose, it decreased blood pressure and heart rate. In conclusion, sodium houttuyfonate attenuates ventricular remodeling induced by pressure overload in rats. The beneficial effects are in part associated with its alleviating the activation of renin-angiotensin-aldosterone system and decreasing the TNF-alpha level. Furthermore, its function seems to correlate with reduced blood pressure and heart rate.
Authors:
Jian Ping Gao; Chang Xun Chen; Qi Wu; Wei Liang Gu; Xiang Li
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  88     ISSN:  1205-7541     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-23     Completed Date:  2010-11-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  693-701     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, P.R. China.
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MeSH Terms
Descriptor/Qualifier:
Aldosterone / blood
Alkanes / pharmacology*
Angiotensin II / metabolism
Animals
Aorta, Abdominal
Blood Pressure / drug effects
Collagen / metabolism
Constriction
Heart Failure / prevention & control
Male
Myocytes, Cardiac / drug effects,  pathology
Rats
Rats, Sprague-Dawley
Renin-Angiotensin System / drug effects
Sulfites / pharmacology*
Tumor Necrosis Factor-alpha / blood
Ventricular Function, Left / drug effects
Ventricular Remodeling / drug effects*,  physiology
Chemical
Reg. No./Substance:
0/Alkanes; 0/Sulfites; 0/Tumor Necrosis Factor-alpha; 0/sodium houttuyfonate; 11128-99-7/Angiotensin II; 52-39-1/Aldosterone; 9007-34-5/Collagen

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