| Effect of sodium chloride and sorbitol infusions on vascular angiotensin reactivity during third trimester pregnancy. | |
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MedLine Citation:
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PMID: 7200346 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Normal pregnancy is associated with refractoriness to the pressor effects of i.v. administered angiotensin II (A II). In pre-eclampsia, this refractoriness to A II is lost several weeks prior to the increase of blood pressure. Infusions of 200 ml of 3% saline or of 40% sorbitol over 30 min, or administration of 2,000 ml of normal saline infused over 2 h, respectively, resulted in an increased vascular angiotensin sensitivity. The effective angiotensin pressor dose (APD) decreased significantly after each test substance (decrease of the mean APD 14.5% after 3% saline, 24% after 40% sorbitol and 25% after normal saline). The data confirm the hypothesis that the principal determinant of pressor responsiveness to A II during pregnancy is arteriolar response; this seems to be modulated by alterations in the sodium content of the vessel wall. |
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Authors:
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T Oney; H Kaulhausen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of gynecology Volume: 231 ISSN: 0170-9925 ISO Abbreviation: Arch. Gynecol. Publication Date: 1982 |
Date Detail:
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Created Date: 1982-06-21 Completed Date: 1982-06-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7901051 Medline TA: Arch Gynecol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 99-105 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Angiotensin Amide / pharmacology Arterioles / drug effects Blood Vessels / drug effects* Drug Interactions Female Humans Pre-Eclampsia / physiopathology Pregnancy Pregnancy Trimester, Third* Sodium Chloride / pharmacology* Sorbitol / pharmacology* |
| Chemical | |
Reg. No./Substance:
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50-70-4/Sorbitol; 53-73-6/Angiotensin Amide; 7647-14-5/Sodium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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