Document Detail

Effect of sodium chloride and sorbitol infusions on vascular angiotensin reactivity during third trimester pregnancy.
MedLine Citation:
PMID:  7200346     Owner:  NLM     Status:  MEDLINE    
Normal pregnancy is associated with refractoriness to the pressor effects of i.v. administered angiotensin II (A II). In pre-eclampsia, this refractoriness to A II is lost several weeks prior to the increase of blood pressure. Infusions of 200 ml of 3% saline or of 40% sorbitol over 30 min, or administration of 2,000 ml of normal saline infused over 2 h, respectively, resulted in an increased vascular angiotensin sensitivity. The effective angiotensin pressor dose (APD) decreased significantly after each test substance (decrease of the mean APD 14.5% after 3% saline, 24% after 40% sorbitol and 25% after normal saline). The data confirm the hypothesis that the principal determinant of pressor responsiveness to A II during pregnancy is arteriolar response; this seems to be modulated by alterations in the sodium content of the vessel wall.
T Oney; H Kaulhausen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of gynecology     Volume:  231     ISSN:  0170-9925     ISO Abbreviation:  Arch. Gynecol.     Publication Date:  1982  
Date Detail:
Created Date:  1982-06-21     Completed Date:  1982-06-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7901051     Medline TA:  Arch Gynecol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  99-105     Citation Subset:  IM    
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MeSH Terms
Angiotensin Amide / pharmacology
Arterioles / drug effects
Blood Vessels / drug effects*
Drug Interactions
Pre-Eclampsia / physiopathology
Pregnancy Trimester, Third*
Sodium Chloride / pharmacology*
Sorbitol / pharmacology*
Reg. No./Substance:
50-70-4/Sorbitol; 53-73-6/Angiotensin Amide; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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