Document Detail

Effect of sodium chloride- and sodium bicarbonate-rich mineral water on blood pressure and metabolic parameters in elderly normotensive individuals: a randomized double-blind crossover trial.
MedLine Citation:
PMID:  12013486     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the effect of sodium chloride- and sodium bicarbonate-rich mineral water on blood pressure and parameters of glucose and lipid metabolism in elderly normotensive individuals. METHODS: We examined 21 healthy men and women aged 60-72 years in a randomized, placebo-controlled, double-blind crossover trial. After reducing dietary salt intake to below 100 mmol/day, study participants were randomly assigned to drink 1.5 l daily of a sodium chloride-rich (sodium 84.5 mmol/l, chloride 63.7 mmol/l, bicarbonate 21.9 mmol/l), a sodium bicarbonate-rich (sodium 39.3 mmol/l, chloride 6.5 mmol/l, bicarbonate 48.8 mmol/l) and a low-sodium (placebo: sodium, chloride and bicarbonate < 0.02 mmol/l) mineral water for 4 weeks each in a three-phase crossover order. Each phase was separated by a 2-week washout period in which the study participants remained on a low-salt diet. Compliance was assessed by biweekly urinary electrolyte excretion and five study participants were excluded from analysis for failing to complete the trial or to fulfil the compliance criteria. RESULTS: Mean arterial blood pressure was significantly lower during the periods of consuming low-sodium -7.0 +/- 7.2 mmHg, P < 0.001) or sodium bicarbonate-rich (-5.7 +/- 6.4 mmHg, P < 0.05) water than at baseline. In contrast, blood pressure during the phase of drinking sodium chloride-rich water was identical to that at baseline. Ambulatory 24 h blood pressure, oral glucose tolerance and plasma lipids were not affected by the different regimens. Urinary calcium excretion was significantly reduced by drinking low-sodium or sodium bicarbonate-rich water but was unchanged under the sodium chloride-rich water. CONCLUSION: Consumption of sodium chloride-rich mineral water can abolish the blood pressure reduction induced by dietary salt restriction in elderly individuals. Sodium bicarbonate-rich mineral water in conjunction with a low-salt diet may have a beneficial effect on calcium homeostasis.
U Schorr; A Distler; A M Sharma
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of hypertension     Volume:  14     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  2002-05-15     Completed Date:  2002-06-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  131-5     Citation Subset:  IM    
Department of Internal Medicine, Universitätsklinikum Benjamin Franklin, Free University of Berlin, Germany.
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MeSH Terms
Aldosterone / blood
Atrial Natriuretic Factor / blood,  drug effects
Blood Glucose / drug effects
Blood Pressure / drug effects*
Cross-Over Studies
Double-Blind Method
Glomerular Filtration Rate / drug effects
Insulin / blood
Lipids / blood
Middle Aged
Mineral Waters* / analysis
Natriuresis / drug effects
Reference Values
Renin / blood,  drug effects
Sodium Bicarbonate / pharmacology*
Sodium Chloride / pharmacology*
Reg. No./Substance:
0/Blood Glucose; 0/Lipids; 11061-68-0/Insulin; 144-55-8/Sodium Bicarbonate; 52-39-1/Aldosterone; 7647-14-5/Sodium Chloride; 85637-73-6/Atrial Natriuretic Factor; EC

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