Document Detail


Effect of sodium caprate on the oral absorptions of danshensu and salvianolic acid B.
MedLine Citation:
PMID:  19555749     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The current study aims to investigate the effect of sodium caprate on the intestinal absorption and bioavailabilities of danshensu and salvianolic acid B, the major active components in Salvia miltiorrhiza Bge (Danshen). Biopharmaceutics and pharmacokinetics properties of the two compounds have been characterized by in vitro, in situ models as well as in vivo in rats. Based on the identified biopharmaceutics characteristics of the two compounds, effect of sodium carparate as absorption enhancer on the intestinal absorption and pharmacokinetics of danshensu and salvianolic acid B in pure compound form as well as extract form were investigated both in vitro and in vivo. Both danshensu and salvianolic acid B demonstrated very limited intestinal permeabilities, leading to oral bioavailabilities of only 11.09% and 3.90% in rats, respectively. Results from both in vitro and in vivo studies consistently indicated that sodium caprate could significantly enhance intestinal permeabilities as well as the in vivo bioavailabilities of both danshensu and salvianolic acid B. The current findings not only identified the usefulness of sodium caprate for the improved delivery of Danshen product but also demonstrated the importance of biopharmaceutics characterization in the dosage form development of traditional Chinese medicine.
Authors:
Limin Zhou; Moses S S Chow; Zhong Zuo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-23
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  379     ISSN:  1873-3476     ISO Abbreviation:  -     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-21     Completed Date:  2009-10-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  109-18     Citation Subset:  IM    
Affiliation:
School of Pharmacy, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, PR China.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Benzofurans / pharmacokinetics*
Biological Availability
Caco-2 Cells
Decanoic Acids / chemistry*
Excipients / chemistry*
Humans
Intestinal Absorption
Lactates / pharmacokinetics*
Male
Permeability
Rats
Rats, Sprague-Dawley
Salvia miltiorrhiza / chemistry
Chemical
Reg. No./Substance:
0/Benzofurans; 0/Decanoic Acids; 0/Excipients; 0/Lactates; 115939-25-8/salvianolic acid B; 23028-17-3/3,4-dihydroxyphenyllactic acid; 334-48-5/decanoic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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