| Effect of sodium butyric acid, sodium valerianic acid, and osmolarity on contractility of specimens of intestinal wall obtained from the cecum and spiral colon of healthy cows. | |
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MedLine Citation:
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PMID: 10850845 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the effect of various concentrations of sodium butyric acid and sodium valerianic acid, as well as various osmolarities, on contractility of ex-vivo intestinal wall specimens obtained from the cecum and spiral colon of each of several healthy cows. SAMPLE POPULATION: Full-thickness preparations of intestinal wall, dissected parallel to the longitudinal smooth muscle layers, harvested from freshly slaughtered healthy cows. PROCEDURE: Specimens of intestinal wall were incubated for 5 minutes with various concentrations of sodium butyric acid and sodium valerianic acid as well as various osmolar concentrations of NaCl, using a crossover design. Isometric contractions were induced 7 times with carbachol (CH; 5 X 10(-6) mol/L). Contractility was defined as the maximum amplitude of contraction and the amplitude of contraction 2 minutes after addition of CH. RESULTS: Repeated addition of CH did not result in a significant effect on contractility of specimens from the cecum and spiral colon. Contractility after addition of CH was not significantly affected by prior incubation with various concentrations of sodium butyric acid or sodium valerianic acid or after an increase of osmolarity. Maximum amplitude of contraction was significantly higher in specimens from the spiral colon, compared with specimens from the cecum. CONCLUSIONS: Increases in concentrations of sodium butyric acid or sodium valerianic acid and increases in osmolarity did not inhibit contractility of intestinal wall specimens from the cecum and spiral colon of a group of healthy cows. |
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Authors:
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M Allemann; R Eicher; M Mevissen; R Haltiner; M Meylan; A Steiner |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of veterinary research Volume: 61 ISSN: 0002-9645 ISO Abbreviation: Am. J. Vet. Res. Publication Date: 2000 Jun |
Date Detail:
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Created Date: 2000-10-19 Completed Date: 2000-10-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375011 Medline TA: Am J Vet Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 678-83 Citation Subset: IM |
Affiliation:
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Clinic for Food Animals and Horses, University of Bern, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Butyric Acid / pharmacology* Carbachol / administration & dosage Cattle Cattle Diseases / etiology, physiopathology Cecum / drug effects*, physiopathology Cholinergic Agonists / administration & dosage Colon / drug effects*, physiopathology Cross-Over Studies Female Intestinal Diseases / etiology, physiopathology, veterinary Multivariate Analysis Muscle Contraction / drug effects Muscle, Smooth / drug effects* Osmolar Concentration Pentanoic Acids / pharmacology* Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
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0/Cholinergic Agonists; 0/Pentanoic Acids; 107-92-6/Butyric Acid; 109-52-4/n-pentanoic acid; 51-83-2/Carbachol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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