Document Detail


Effect of sodium on blood pressure, cardiac hypertrophy, and angiotensin receptor expression in rats.
MedLine Citation:
PMID:  14700507     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Sodium-induced hypertensive cardiac hypertrophy is related to pressure and volume overload. METHODS: Wistar rats were exposed to low and high sodium diet for 8 weeks. Angiotensin II receptor mRNA, abundance of p38 mitogen-activated protein kinase (p38MAPK), vasoconstriction of aortic rings, and angiotensin II-induced calcium increase were investigated. RESULTS: Rats on high sodium diet showed significantly elevated blood pressure. Heart weight, AT1 receptor mRNA in cardiac and aortic tissues, and abundance of p38MAPK were significantly increased in rats on high sodium diet. CONCLUSIONS: Increased AT1 receptor expression and angiotensin II-induced calcium increase are compensatory effects in sodium-induced hypertension.
Authors:
Zhiming Zhu; Shanjun Zhu; Ziqian Wu; Daoyan Liu; Yongjian Yang; Xianmei Wang; Jijin Zhu; Martin Tepel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of hypertension     Volume:  17     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2003-12-31     Completed Date:  2004-08-12     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  21-4     Citation Subset:  IM    
Affiliation:
Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing, PR China. zhuzm@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Aorta / drug effects
Blood Pressure / drug effects*
Cardiomegaly / etiology*
Disease Models, Animal
Gene Expression / drug effects
Mitogen-Activated Protein Kinases / drug effects*
Rats
Rats, Wistar
Receptors, Angiotensin / drug effects*
Sodium, Dietary / adverse effects,  pharmacology*
Chemical
Reg. No./Substance:
0/Receptors, Angiotensin; 0/Sodium, Dietary; EC 2.7.11.24/Mitogen-Activated Protein Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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