Document Detail


Effect of sodium azulene sulfonate on capsaicin-induced pharyngitis in rats.
MedLine Citation:
PMID:  15667596     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sodium azulene sulfonate is a water-soluble derivative of azulene which is an antiinflammatory component of chamomile of the family of Asteraceae. Sodium azulene sulfonate is clinically used as a therapeutic agent in the treatment of pharyngitis as well as other inflammatory diseases such as tonsillitis, stomatitis and conjunctivitis. There has been no documentation on the effect of sodium azulene sulfonate on pharyngitis in laboratory models, probably because of no availability of such models. We recently established a pharyngitis model using capsaicin application on pharyngeal mucosa in rats. The present study investigated the antipharyngitis activity of sodium azulene sulfonate comparing with those of ruthenium red (vanilloid receptor antagonist, 8.5 and 85 mg/ml), ascorbic acid (antioxidative compound, 100 microg/ml), povidone iodine (gargle as disinfectant, oxidative compound, 5 and 20 mg/ml) and diclofenac sodium (cyclooxygenase inhibitor, 0.1 and 1 mg/ml). As an antipharyngeal effect, the capsaicin-induced plasma exudation in the pharyngeal mucosa of the rat was evaluated. The capsaicin-induced plasma exudation in the pharyngeal mucosa was inhibited by sodium azulene sulfonate (100 and 200 microg/ml) as well as ruthenium red and ascorbic acid, but not by povidone iodine and dicrofenac sodium; povidone iodine rather promoted the plasma exudation. In conclusion, the antipharyngitis effect of sodium azulene sulfonate was demonstrated for the first time in a laboratory model. Although the mechanism by which sodium azulene sulfonate inhibited the capsaicin-induced pharyngitis is not yet unraveled, antioxidative effect, but not inhibitory effect on cyclooxygenase pathway, might be involved.
Authors:
Hiroyasu Sakai; Miwa Misawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Basic & clinical pharmacology & toxicology     Volume:  96     ISSN:  1742-7835     ISO Abbreviation:  Basic Clin. Pharmacol. Toxicol.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-01-25     Completed Date:  2005-05-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101208422     Medline TA:  Basic Clin Pharmacol Toxicol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  54-9     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, School of Pharmacy, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo, Japan. sakai@hoshi.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants / pharmacology
Ascorbic Acid / pharmacology
Azulenes
Capsaicin*
Cyclooxygenase Inhibitors / pharmacology
Diclofenac / pharmacology
Exudates and Transudates / drug effects
Male
Pharyngitis / chemically induced*,  prevention & control*
Povidone / pharmacology
Rats
Rats, Wistar
Receptors, Drug / antagonists & inhibitors
Ruthenium Red / pharmacology
Sesquiterpenes / pharmacology*
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Azulenes; 0/Cyclooxygenase Inhibitors; 0/Receptors, Drug; 0/Sesquiterpenes; 11103-72-3/Ruthenium Red; 15307-86-5/Diclofenac; 28802-61-1/azulene SN; 404-86-4/Capsaicin; 50-81-7/Ascorbic Acid; 9003-39-8/Povidone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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