Document Detail

Effect of smoking on the results of a chlorhexidine digluconate treatment extended up to 3 months after scaling and root planing-a pilot study.
MedLine Citation:
PMID:  21716983     Owner:  NLM     Status:  MEDLINE    
The aim of the study was to evaluate the impact of smoking on a prolongated chlorhexidine digluconate regimen after scaling and root planing. Forty-two smokers (test group) and 85 nonsmoking patients (control group) with generalized chronic periodontitis were examined for clinical attachment level (CAL), probing depth (PD), bleeding on probing (BoP), and Plaque Index (Pl) at baseline and after 1 and 3 months. During scaling and root planing, a 0.2% chlorhexidine digluconate solution and a 1% chlorhexidine digluconate gel were used. The subjects used a 0.2% chlorhexidine digluconate solution twice daily for 3 months. The Mann-Whitney U and Wilcoxon tests were used for statistical analysis. There were significant improvements of all studied variables after 1 and 3 months in both groups. After 3 months, the mean improvement in the test group was 1.62 mm for CAL, 2.85 mm for PD, and 48% for BoP; in the control group, the values were 2.18 mm for CAL, 2.81 mm for PD, and 47% for BoP. Only the maximum changes of CAL between 1 and 3 months (test group, 0.32 mm vs 0.69 mm in the control group) and PD (test group, 0.47 mm vs 0.76 mm in the control group) were significantly different between the groups (P < .05 and P = .05, respectively). The present data appear to suggest that the use of chlorhexidine digluconate twice daily during a period of 3 months following nonsurgical periodontal therapy may result in significant clinical improvements in smokers and nonsmokers.
Stefan-Ioan Stratul; Anton Sculean; Darian Rusu; Andreea Didilescu; Adrian Kasaj; Holger Jentsch
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Publication Detail:
Type:  Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Quintessence international (Berlin, Germany : 1985)     Volume:  42     ISSN:  1936-7163     ISO Abbreviation:  Quintessence Int     Publication Date:    2011 Jul-Aug
Date Detail:
Created Date:  2011-06-30     Completed Date:  2011-11-03     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0342677     Medline TA:  Quintessence Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  555-63     Citation Subset:  D    
Department of Periodontology, Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
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MeSH Terms
Anti-Infective Agents, Local / adverse effects,  therapeutic use*
Chlorhexidine / adverse effects,  analogs & derivatives*,  therapeutic use
Chronic Periodontitis / prevention & control,  therapy*
Dental Plaque Index
Dental Scaling*
Follow-Up Studies
Gingival Hemorrhage / prevention & control,  therapy
Middle Aged
Mouthwashes / therapeutic use
Periodontal Attachment Loss / prevention & control,  therapy
Periodontal Pocket / prevention & control,  therapy
Pilot Projects
Prospective Studies
Root Planing*
Taste Disorders / chemically induced
Tooth Discoloration / chemically induced
Reg. No./Substance:
0/Anti-Infective Agents, Local; 0/Gels; 0/Mouthwashes; 55-56-1/Chlorhexidine; MOR84MUD8E/chlorhexidine gluconate

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