Document Detail


Effect of smoking habits and timolol treatment on mortality and reinfarction in patients surviving acute myocardial infarction.
MedLine Citation:
PMID:  3893489     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Norwegian Multicenter Group Study noted the effect of smoking habits before and after myocardial infarction and their relation to mortality and reinfarction rate after treatment with timolol in patients surviving acute myocardial infarction. The mean follow up period was 17.3 (range 12-33) months. No relation was found between initial smoking habits and risk category after infarction or between initial smoking habits and later outcome. At the time of their first infarct smokers were seven years younger than non-smokers. One moth after infarction nearly 60% of the smokers had stopped smoking completely. A significantly lower incidence of early cardiac death and lower total mortality was found in patients treated with timolol in both those who continued smoking and in the combined non-smoking groups and a significantly lower reinfarction rate among non-smokers. Cessation of smoking alone was associated with a reduced reinfarction rate by 45% but a non-significant reduction in mortality by 26%. It is concluded that treatment with timolol and cessation of smoking have an additive effect in reducing mortality and reinfarction rate after myocardial infarction.
Authors:
P K Rønnevik; T Gundersen; A M Abrahamsen
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  British heart journal     Volume:  54     ISSN:  0007-0769     ISO Abbreviation:  Br Heart J     Publication Date:  1985 Aug 
Date Detail:
Created Date:  1985-09-24     Completed Date:  1985-09-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370634     Medline TA:  Br Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  134-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Clinical Trials as Topic
Female
Humans
Male
Middle Aged
Myocardial Infarction / mortality,  prevention & control*
Random Allocation
Recurrence
Risk
Smoking*
Timolol / therapeutic use*
Chemical
Reg. No./Substance:
26839-75-8/Timolol
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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