Document Detail


Effect of smoking cessation on markers of inflammation and endothelial cell activation among individuals with high risk for cardiovascular disease.
MedLine Citation:
PMID:  17852807     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To prospectively determine the effect of smoking cessation on markers of inflammation and endothelial cell activation. MATERIAL AND METHODS: Thirty male and 22 female smokers of >7 cigarettes daily, aged 32-64 years with cardiovascular disease (CVD) or additional risk factors to smoking, participated in a program of smoking cessation with a follow-up period of 1 year. Cessation was validated by carbon monoxide measurement in expired breath, and 41 of the patients completed the study (17 quitters and 24 non-quitters). Plasma samples were drawn at baseline and after 1 year, and inflammatory markers were analyzed by enzyme immunoassays. Peripheral blood mononuclear cells (PBMCs) were isolated at baseline and 1 year in 6 quitters and 6 smokers and mRNA levels of interleukin-8 (IL-8), tumor necrosis factor x (TNFx) and intercellular adhesion molecule 1 (ICAM-1) were analyzed by real-time quantitative RT-PCR. RESULTS: Our main findings were: (i) While the concentration of soluble (s) ICAM-1 decreased in quitters, it increased in smokers, with a significant difference in changes between the groups (p=0.04). (ii) While there was only minor change in mRNA levels of IL-8 in smokers, those who stopped smoking showed a decrease in the gene expression of IL-8 (p < 0.09; comparing difference in changes). (iii) Concentrations of the other measured parameters (E-selectin, IL-6, sCD40 ligand, TNFx, von Willebrand factor, and C-reactive protein) were unchanged during follow-up in both groups. CONCLUSION: Smoking cessation induced a reduction in ICAM-1, suggesting a novel mechanism for the rapid reduction in the risk of CVD following smoking cessation.
Authors:
B Halvorsen; E Lund Sagen; T Ueland; P Aukrust; S Tonstad
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation     Volume:  67     ISSN:  0036-5513     ISO Abbreviation:  Scand. J. Clin. Lab. Invest.     Publication Date:  2007  
Date Detail:
Created Date:  2007-12-07     Completed Date:  2008-01-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404375     Medline TA:  Scand J Clin Lab Invest     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  604-11     Citation Subset:  IM    
Affiliation:
Institute for Internal Medicine Research, University of Oslo, Oslo, Norway. bente.halvorsen@medisin.uio.no
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers / blood
C-Reactive Protein / analysis
Carbon Monoxide / analysis
Cardiovascular Diseases / blood*
Endothelial Cells / metabolism*
Female
Follow-Up Studies
Humans
Inflammation / blood*
Intercellular Adhesion Molecule-1 / metabolism
Interleukin-8 / blood
Male
Middle Aged
Reverse Transcriptase Polymerase Chain Reaction
Risk Reduction Behavior
Smoking / blood
Smoking Cessation*
Statistics, Nonparametric
Tumor Necrosis Factor-alpha / blood
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Interleukin-8; 0/Tumor Necrosis Factor-alpha; 126547-89-5/Intercellular Adhesion Molecule-1; 630-08-0/Carbon Monoxide; 9007-41-4/C-Reactive Protein

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