Document Detail

Effect of small motor unit potentials on the motor unit number estimate.
MedLine Citation:
PMID:  18508351     Owner:  NLM     Status:  MEDLINE    
Small surface motor unit potentials (S-MUPs) may have a negative influence on the variability of the motor unit number estimate (MUNE). According to published consensus criteria S-MUPs with a negative peak amplitude smaller than 10 muV should be omitted. The effect of omitting small S-MUPs on the MUNE was evaluated using a simulation model. The model incorporated a healthy and amyotrophic lateral sclerosis (ALS) distribution formed with real S-MUPs. Using a random drawing process the MUNE was calculated with and without small S-MUPs. In the healthy population 27% of all S-MUPs were small. MUNE determined without these S-MUPs was marginally less variable. However, MUNE values dropped about 24% at a sample size of 20. In ALS, only 12% of the total population of 130 S-MUPs were small. MUNE dropped about 12% without the small S-MUPs. By omitting small S-MUPs the differences between the healthy and ALS distributions become smaller. Therefore, incorporating small S-MUPs in the estimate is suggested.
Johannes P van Dijk; Machiel J Zwarts; Helenius J Schelhaas; Dick F Stegeman
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Muscle & nerve     Volume:  38     ISSN:  0148-639X     ISO Abbreviation:  Muscle Nerve     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-24     Completed Date:  2008-09-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  United States    
Other Details:
Languages:  eng     Pagination:  887-92     Citation Subset:  IM    
Copyright Information:
(c) 2008 Wiley Periodicals, Inc.
Department of Clinical Neurophysiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
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MeSH Terms
Amyotrophic Lateral Sclerosis / pathology,  physiopathology
Cell Count
Computer Simulation
Electrodes, Implanted
Membrane Potentials / physiology
Middle Aged
Motor Neurons / physiology*
Muscle Fibers, Skeletal / physiology*
Sample Size

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