| Effect of small motor unit potentials on the motor unit number estimate. | |
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MedLine Citation:
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PMID: 18508351 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Small surface motor unit potentials (S-MUPs) may have a negative influence on the variability of the motor unit number estimate (MUNE). According to published consensus criteria S-MUPs with a negative peak amplitude smaller than 10 muV should be omitted. The effect of omitting small S-MUPs on the MUNE was evaluated using a simulation model. The model incorporated a healthy and amyotrophic lateral sclerosis (ALS) distribution formed with real S-MUPs. Using a random drawing process the MUNE was calculated with and without small S-MUPs. In the healthy population 27% of all S-MUPs were small. MUNE determined without these S-MUPs was marginally less variable. However, MUNE values dropped about 24% at a sample size of 20. In ALS, only 12% of the total population of 130 S-MUPs were small. MUNE dropped about 12% without the small S-MUPs. By omitting small S-MUPs the differences between the healthy and ALS distributions become smaller. Therefore, incorporating small S-MUPs in the estimate is suggested. |
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Authors:
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Johannes P van Dijk; Machiel J Zwarts; Helenius J Schelhaas; Dick F Stegeman |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Muscle & nerve Volume: 38 ISSN: 0148-639X ISO Abbreviation: Muscle Nerve Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-06-24 Completed Date: 2008-09-02 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7803146 Medline TA: Muscle Nerve Country: United States |
Other Details:
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Languages: eng Pagination: 887-92 Citation Subset: IM |
Copyright Information:
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(c) 2008 Wiley Periodicals, Inc. |
Affiliation:
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Department of Clinical Neurophysiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. h.vandijk@neuro.umcn.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Amyotrophic Lateral Sclerosis / pathology, physiopathology Cell Count Computer Simulation Electrodes, Implanted Electromyography Female Humans Male Membrane Potentials / physiology Middle Aged Motor Neurons / physiology* Muscle Fibers, Skeletal / physiology* Sample Size |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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