Document Detail

Effect of slow-releasing all-trans-retinoic acid in bioabsorbable polymer on delayed adjustable strabismus surgery in a rabbit model.
MedLine Citation:
PMID:  19589494     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To determine the usefulness of slow-releasing all-trans-retinoic acid (ATRA) in polytetrafluoroethylene (PTFE)/polylactide-co-glycolide (PLGA) for delayed adjustable strabismus surgery. DESIGN: Animal study. METHODS: A prospective, masked-observer, controlled study was performed in 25 rabbits. Fifty rabbit eyes were divided randomly into three groups. After a recession of the superior rectus muscle, a PTFE/PLGA laminate containing ATRA, PTFE alone, or balanced salt solution was applied beneath and over the superior rectus muscle in the PTFE/PLGA/all-trans-retinoic acid group (ATRA group), the polytetrafluoroethylene group (PTFE group), and the control group, respectively. Delayed adjustment was performed once on each superior rectus muscle at 3 or 5 weeks after surgery by a masked observer. RESULTS: In the control group, adjustment was possible in 2 of 5 eyes at 3 weeks after surgery and impossible in any eye at 5 weeks after surgery. In the PTFE and ATRA groups, adjustment was possible in all 10 eyes at 3 and 5 weeks after surgery. On comparing adjustability, a significant difference was observed between the PTFE group and the control group or between the ATRA group and the control group 5 weeks after surgery (P = .0003 and P = .0003, respectively). A significant difference was observed between the ATRA group and the control group in terms of adhesion between superior rectus muscles and sclerae at 5 weeks after surgery (P = .006). CONCLUSIONS: Slow-releasing ATRA in PTFE/PLGA was found to reduce adhesion and to allow delayed adjustment in most eyes for up to 5 weeks after surgery.
Min Joung Lee; Su-Eon Jin; Chong-Kook Kim; Ho-Kyung Choung; Hwa Jung Kim; Jeong-Min Hwang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-07-09
Journal Detail:
Title:  American journal of ophthalmology     Volume:  148     ISSN:  1879-1891     ISO Abbreviation:  Am. J. Ophthalmol.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-28     Completed Date:  2009-10-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370500     Medline TA:  Am J Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  566-72     Citation Subset:  AIM; IM    
Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.
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MeSH Terms
Absorbable Implants*
Delayed-Action Preparations
Drug Delivery Systems*
Fibrosis / prevention & control
Keratolytic Agents / administration & dosage*
Lactic Acid
Oculomotor Muscles / drug effects,  pathology,  surgery*
Ophthalmologic Surgical Procedures
Polyglycolic Acid
Prospective Studies
Strabismus / drug therapy,  pathology,  surgery*
Suture Techniques
Tretinoin / administration & dosage*
Reg. No./Substance:
0/Delayed-Action Preparations; 0/Keratolytic Agents; 0/polylactic acid-polyglycolic acid copolymer; 26009-03-0/Polyglycolic Acid; 302-79-4/Tretinoin; 50-21-5/Lactic Acid; 9002-84-0/Polytetrafluoroethylene

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