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Effect of size of man-made and natural mineral fibers on chemiluminescent response in human monocyte-derived macrophages.
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MedLine Citation:
PMID:  11675268     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fiber size is an important factor in the tumorigenicity of various mineral fibers and asbestos fibers in animal experiments. We examined the time course of the ability to induce lucigenin-dependent chemiluminescence (CL) from human monocyte-derived macrophages exposed to Japan Fibrous Material standard reference samples (glass wool, rock wool, micro glass fiber, two types of refractory ceramic fiber, refractory mullite fiber, potassium titanium whisker, silicon carbide whisker, titanium oxide whisker, and wollastonite). We determined how fiber length or width might modify the response of cells. We found that the patterns of time-dependent increase of CL (sigmoid type) were similar for each sample except wollastonite. We observed a strong correlation between geometric-mean length and ability to induce CL in seven samples > 6 microm in length over the time course (largest r(2) = 0.9760). Although we also observed a close positive correlation between geometric-mean width and the ability to induce CL in eight samples < 1.8 microm in width at 15 min (r(2) = 0.8760), a sample of 2.4 microm in width had a low ability to induce CL. Moreover, the relationship between width and the rate of increase in ability to induce CL had a negative correlation at 30-60 min (largest r(2) = 0.7473). Our findings suggest that the release of superoxide from macrophages occurs nonspecifically for various types of mineral fibers depending on fiber length.
Authors:
M Ohyama; T Otake; K Morinaga
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Environmental health perspectives     Volume:  109     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-24     Completed Date:  2001-12-04     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1033-8     Citation Subset:  IM    
Affiliation:
Osaka Prefectural Institute of Public Health, 1-3-69 Nakamichi, Higashinari-ku, Osaka 537-0025, Japan. ooyama@iph.pref.osaka.jp
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MeSH Terms
Descriptor/Qualifier:
Acridines / analysis
Asbestos / adverse effects*,  pharmacokinetics
Cell Culture Techniques
Chemiluminescent Measurements
Humans
Kinetics
Macrophages / drug effects*
Manufactured Materials
Mineral Fibers / adverse effects
Particle Size
Chemical
Reg. No./Substance:
0/Acridines; 0/Mineral Fibers; 1332-21-4/Asbestos; 2315-97-1/10,10'-dimethyl-9,9'-biacridinium
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): Environ Health Perspect
ISSN: 0091-6765
Article Information
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Print publication date: Month: 10 Year: 2001
Volume: 109 Issue: 10
First Page: 1033 Last Page: 1038
ID: 1242080
PubMed Id: 11675268
Publisher Item Identifier: sc271_5_1835

Effect of size of man-made and natural mineral fibers on chemiluminescent response in human monocyte-derived macrophages.
M Ohyama
T Otake
K Morinaga
Osaka Prefectural Institute of Public Health, 1-3-69 Nakamichi, Higashinari-ku, Osaka 537-0025, Japan. ooyama@iph.pref.osaka.jp


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