Document Detail

Effect of six-hour exposure to nitrogen dioxide on early-phase nasal response to allergen challenge in patients with a history of seasonal allergic rhinitis.
MedLine Citation:
PMID:  7499684     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Recent studies have suggested that exposure to air pollutants may enhance the airway responsiveness of susceptible individuals to inhaled allergen. METHODS: To investigate the effect of exposure to nitrogen dioxide (NO2) on nasal airways resistance (NAR) and inflammatory mediators in nasal lavage fluid, eight subjects with a history of seasonal allergic rhinitis, who were tested out of season, were exposed in a randomized single-blind, crossover study to either air or 400 ppb NO2 for 6 hours. The changes in NAR and eosinophil cationic protein (ECP), mast cell tryptase (MCT), neutrophil myeloperoxidase (MPO), and interleukin-8 (IL-8) in nasal lavage fluid before and after exposure were evaluated. Another group of eight subjects with a history of seasonal allergic rhinitis were also randomized to exposure to air or 400 ppb NO2 for 6 hours and then challenged with allergen, before evaluation for changes in NAR and changes in ECP, MCT, MPO, and IL-8 in nasal lavage fluid. RESULTS: Exposure to air or NO2 did not alter either NAR or the levels of ECP, MCT, MPO, or IL-8 in nasal lavage fluid. Allergen challenge after exposure to both air and NO2 significantly (p < 0.05) increased levels of MCT, but not MPO and IL-8 in the nasal lavage fluid. In addition, allergen challenge after exposure to NO2 but not air, significantly increased levels of only ECP in nasal lavage fluid (p < 0.05). CONCLUSIONS: These results suggest that acute exposure to NO2 at concentrations found at the curbside in heavy traffic during episodes of pollution, may "prime" eosinophils for subsequent activation by allergen in individuals with a history of seasonal allergic rhinitis.
J H Wang; J L Devalia; J M Duddle; S A Hamilton; R J Davies
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  96     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1996-01-16     Completed Date:  1996-01-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  669-76     Citation Subset:  AIM; IM    
Department of Respiratory Medicine and Allergy, St. Bartholomew's Hospital, London.
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MeSH Terms
Airway Resistance
Allergens / administration & dosage,  pharmacology*
Blood Proteins / metabolism
Cross-Over Studies
Eosinophil Granule Proteins
Inflammation Mediators / metabolism
Interleukin-8 / metabolism
Mast Cells / enzymology
Middle Aged
Nasal Lavage Fluid / chemistry
Nasal Mucosa / drug effects,  metabolism*
Nasal Provocation Tests
Nebulizers and Vaporizers
Nitrogen Dioxide / administration & dosage,  pharmacology*
Peroxidase / metabolism
Rhinitis, Allergic, Seasonal / complications,  metabolism*
Serine Endopeptidases / metabolism
Single-Blind Method
Reg. No./Substance:
0/Allergens; 0/Blood Proteins; 0/Eosinophil Granule Proteins; 0/Inflammation Mediators; 0/Interleukin-8; 10102-44-0/Nitrogen Dioxide; EC; EC 3.1.-/Ribonucleases; EC 3.4.21.-/Serine Endopeptidases; EC 3.4.21.-/chymase 2; EC; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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