| Effect of six days of staging on physiologic adjustments and acute mountain sickness during ascent to 4300 meters. | |
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MedLine Citation:
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PMID: 19775215 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study determined the effectiveness of 6 days (d) of staging at 2200 m on physiologic adjustments and acute mountain sickness (AMS) during rapid, high-risk ascent to 4300 m. Eleven sea-level (SL) resident men (means +/- SD; 21 +/- 3 yr; 78 +/- 13 kg) completed resting measures of end-tidal CO(2) (Petco(2)), arterial oxygen saturation (Sao(2)), heart rate (HR), and mean arterial pressure (MAP) at SL and within 1 h of exposure to 4300 m in a hypobaric chamber prior to 6 d of staging at 2200 m (preSTG) and on the summit of Pikes Peak following 6 d of staging at 2200 m (postSTG). Immediately following resting ventilation measures, all performed submaximal exercise ( approximately 55% of altitude-specific maximal oxygen uptake) for approximately 2 h on a bicycle ergometer to induce higher levels of AMS. AMS-C, calculated from the Environmental Symptoms Questionnaire, was measured following 4 h and 8 h of exposure at preSTG and postSTG, and the mean was calculated. Resting Petco(2) (mmHg) was unchanged from SL (39.8 +/- 2.6) to preSTG (39.3 +/- 3.0), but decreased (p < 0.05) from preSTG to postSTG (32.8 +/- 2.6). Resting Sao(2) (%) decreased (p < 0.05) from SL (97 +/- 2) to preSTG (80 +/- 4) and increased (p < 0.05) from preSTG to postSTG (83 +/- 3). Resting HR (bpm) and MAP (mmHg) did not change in any of the test conditions. The incidence and severity of AMS-C decreased (p < 0.05) from preSTG (91 +/- 30%; 1.05 +/- 0.56) to postSTG (45 +/- 53%; 0.59 +/- 0.43), respectively. These results suggest that modest physiologic adjustments induced by staging for 6 d at 2200 m reduced the incidence and severity of AMS during rapid, high-risk ascent to 4300 m. |
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Authors:
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Beth A Beidleman; Charles S Fulco; Stephen R Muza; Paul B Rock; Janet E Staab; Vincent A Forte; Michael D Brothers; Allen Cymerman |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: High altitude medicine & biology Volume: 10 ISSN: 1557-8682 ISO Abbreviation: High Alt. Med. Biol. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-09-24 Completed Date: 2009-12-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901183 Medline TA: High Alt Med Biol Country: United States |
Other Details:
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Languages: eng Pagination: 253-60 Citation Subset: IM; S |
Affiliation:
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Thermal and Mountain Medicine Division, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts 01760, USA. beth.beidleman@us.army.mil |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological
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physiology* Adult Altitude* Altitude Sickness / blood, physiopathology* Anoxia / physiopathology* Blood Pressure / physiology Carbon Dioxide / blood Cross-Over Studies Environment, Controlled* Exercise Test Heart Rate / physiology Humans Male Oxygen / blood Prospective Studies |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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