Document Detail

Effect of the site of assisted hatching on vitrified-warmed blastocyst transfer cycles: a prospective randomized study.
MedLine Citation:
PMID:  23558770     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To assess the effect of assisted hatching (AH) site on the clinical outcomes in vitrified-warmed blastocyst transfer cycles.
METHODS: A total of 160 women who underwent vitrified-warmed blastocyst transfer cycles were randomized to either the ICM group (AH performing at the site near the inner cell mess, ICM), or the TE group (AH performing at the site opposite to the ICM). AH with laser zona drilling was performed 20 or 30 min after thawing once the ICM can be detected. Clinical pregnancy rate, implantation rate, live birth rate and the occurrence rate of monozygotic twins (MZT) pregnancy after transfer of these two groups were compared.
RESULTS: No significant difference was found in the clinical pregnancy rate (63.8% vs. 67.5%), implantation rate (51.7% vs. 53.6%) and live birth rate (57.5% vs. 62.5%) between the ICM group and the TE group. The occurrence rate of MZT was comparable between the two groups (3.9% vs. 5.6%).
CONCLUSIONS: The site of assisted hatching has no influence on the implantation, pregnancy and live birth rate in human vitrified-warmed blastocyst transfer cycles.
Xinling Ren; Qun Liu; Wen Chen; Guijin Zhu; Hanwang Zhang
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2013-04-05
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  30     ISSN:  1573-7330     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-27     Completed Date:  2013-11-13     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  691-7     Citation Subset:  IM    
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MeSH Terms
Blastocyst Inner Cell Mass / cytology
Embryo Transfer / methods*
Fertilization in Vitro
Microinjections / adverse effects,  methods*
Oocytes / cytology
Pregnancy Rate
Prospective Studies
Sperm Injections, Intracytoplasmic / adverse effects,  methods*
Zona Pellucida / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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