| Effect of a single transfusion of donor-specific and nonspecific blood on skin allograft survival in mice. | |
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MedLine Citation:
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PMID: 7008289 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of a single transfusion of donor-specific or nonspecific blood on skin allograft survival was studied in ALS-treated mice. In the weak H-2-incompatible C3H/He to B6AF1 combination, transfusion of outbred CF1 blood induced significant prolongation of C3H/He skin graft survival when given over a wide interval of days between transfusion and skin grafting. In contrast, donor-specific C3H/He blood was effective only when given 10 days before grafting. Transfusion of either red blood cells or lymphocytes separated from CF1 or C3H/He whole blood also prolonged C3H/He skin graft survival. In the relatively strong H-2 incompatible DBA/2 to B6AF1 combination, significant prolongation of DBA/2 skin grafts was induced only by transfusion of donor-specific DBA/2- and H-2-compatible BALB/c blood. A single transfusion of C3H/He or CF1 blood failed to prolong DBA/2 skin graft survival. In the strong H-2-incompatible DBA/1 to B6AF1 combination, donor-specific DBA/1 blood was effective in prolonging DBA/1 skin graft survival. These results demonstrate that the effectiveness of donor-specific or nonspecific blood is dependent on (1) the degree of H-2 incompatibility of donor-recipient pairs and (2) timing of the blood transfusion relative to skin grafting. |
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Authors:
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H Okazaki; T Maki; M Wood; A P Monaco |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Transplantation Volume: 30 ISSN: 0041-1337 ISO Abbreviation: Transplantation Publication Date: 1980 Dec |
Date Detail:
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Created Date: 1981-04-21 Completed Date: 1981-04-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0132144 Medline TA: Transplantation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 421-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Transfusion* Erythrocyte Transfusion Graft Survival* H-2 Antigens / genetics Leukocyte Transfusion Mice Mice, Inbred C3H / genetics Mice, Inbred DBA / genetics Skin Transplantation* Time Factors Transplantation, Homologous |
| Grant Support | |
ID/Acronym/Agency:
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AI 14551-03/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/H-2 Antigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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