| Effect of a single injection of human chorionic gonadotrophin on testosterone levels in testicular interstitial fluid, and in testicular and peripheral venous blood in adult rats. | |
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MedLine Citation:
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PMID: 2754365 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have used a push pull cannula to collect interstitial fluid from the testes of anaesthetized rats at various times after a single injection of human chorionic gonadotrophin (hCG; 50 IU), and compared the levels of testosterone in this fluid with the levels in testicular and peripheral venous blood collected at the same times. Following hCG injection, significant increases in testosterone concentrations were observed in all fluids with notable peaks occurring in interstitial fluid at 2, 8 and 24 h, in testicular venous blood at 2, 8 and 30 h, and in peripheral venous blood at 2, 8, 24 and 72 h. The results demonstrate for the first time that changes in testosterone concentrations in interstitial fluid can be different from those in testicular venous blood. In addition, when testosterone levels in interstitial fluid were compared with levels in testicular venous blood at each time-point, the results suggested that the partitioning of testosterone between these two compartments can be regulated. Furthermore, the changes in both interstitial fluid and testicular venous blood levels of testosterone do not always parallel those in peripheral venous blood, suggesting that changes in testicular blood flow and peripheral clearance rates of testosterone may also be important in the control of circulating testosterone concentrations. |
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Authors:
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S Maddocks; B P Setchell |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of endocrinology Volume: 121 ISSN: 0022-0795 ISO Abbreviation: J. Endocrinol. Publication Date: 1989 May |
Date Detail:
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Created Date: 1989-08-30 Completed Date: 1989-08-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375363 Medline TA: J Endocrinol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 311-6 Citation Subset: IM |
Affiliation:
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Department of Animal Sciences, Waite Agricultural Research Institute, Glen Osmond, South Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chorionic Gonadotropin / pharmacology* Extracellular Space / metabolism Male Rats Testis / blood supply, metabolism Testosterone / blood, metabolism* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 58-22-0/Testosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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