Document Detail

Effect of a single dose of ibuprofen lysinate before embryo transfer on pregnancy rates in cows.
MedLine Citation:
PMID:  11226038     Owner:  NLM     Status:  MEDLINE    
Embryo implantation is a critical step in both cows and humans. The use of ibuprofen lysinate to enhance implantation has been investigated in cattle with the specific aim of improving pregnancy rates after embryo transfer. In this study, heifers (n = 100) were assigned randomly to one of two groups: one group was treated i.m. with 5 mg ibuprofen lysinate kg(-1) body weight 1 h before embryo transfer and a control group received vehicle only. A single embryo was transferred into each recipient cow. There was a significant difference in the number of pregnancies after embryo transfer between cows in the treated (41 of 50; 82%) and control (28 of 50; 56%) groups (P < 0.05). These data indicate that ibuprofen lysinate may be an effective adjunctive treatment for assisted reproduction in cattle. Further studies are needed to clarify whether this effect is associated with the reduction of cyclooxygenase enzyme isoforms during embryo transfer or whether other mechanisms are involved.
M Elli; B Gaffuri; A Frigerio; M Zanardelli; D Covini; M Candiani; M Vignali
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Reproduction (Cambridge, England)     Volume:  121     ISSN:  1470-1626     ISO Abbreviation:  Reproduction     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-08-28     Completed Date:  2001-09-13     Revised Date:  2005-07-19    
Medline Journal Info:
Nlm Unique ID:  100966036     Medline TA:  Reproduction     Country:  England    
Other Details:
Languages:  eng     Pagination:  151-4     Citation Subset:  IM    
II Department of Obstetrics and Gynecology, University of Milano, Via Commenda 12, 20122 Milano, Italy.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*
Embryo Implantation / drug effects
Embryo Transfer / veterinary*
Ibuprofen / administration & dosage*,  analogs & derivatives
Lysine / administration & dosage*,  analogs & derivatives
Prospective Studies
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 15687-27-1/Ibuprofen; 56-87-1/Lysine; 57469-77-9/solufenum

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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