Document Detail

Effect of the single or combined administration of cocaine and testosterone on cardiovascular function and baroreflex activity in unanesthetized rats.
MedLine Citation:
PMID:  22030898     Owner:  NLM     Status:  Publisher    
ABSTRACT: Cocaine and androgenic-anabolic steroids (AAS) abuse have become a serious public health problem. Despite reports of an increase in the incidence of simultaneous illicit use of these substances, potential toxic interactions between cocaine and AAS on the cardiovascular system are unknown. In the present study, we investigated the effect of single or combined administration of testosterone and cocaine for one or 10 consecutive days on basal cardiovascular parameters, baroreflex activity and hemodynamic responses to vasoactive agents in unanesthetized rats.Ten-day combined administration of testosterone and cocaine increased arterial pressure baseline. Changes on arterial pressure were associated with altered baroreflex activity, and impairment of both hypotensive response to intravenous sodium nitroprusside (SNP) and pressor effect of intravenous phenylephrine. Chronic single administration of either testosterone or cocaine did not affect arterial pressure baseline. However, testosterone-treated animals presented rest bradycardia, cardiac hypertrophy, alterations in baroreflex activity, and enhanced response to SNP. Repeated administration of cocaine affected baroreflex activity and impaired vascular responsiveness to both SNP and phenylephrine. One-day single or combined administration of the drugs did not affect any parameter investigated.In conclusion, present results suggest a potential interaction between toxic effects of cocaine and testosterone on cardiovascular activity. Changes on arterial pressure baseline following combined administration of these two drugs may result from alterations in baroreflex activity and impairment of vascular responsiveness to vasoactive agents.
Sheila A Engi; Fábio C Cruz; Rodrigo M Leão; Fernando M A Corrêa; Cleopatra S Planeta; Carlos C Crestani
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-25
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  -     ISSN:  1533-4023     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Laboratory of Pharmacology, Department of Natural Active Principles and Toxicology, School of Pharmaceutical Sciences, São Paulo State University, UNESP, Araraquara, SP, 14801-902, Brazil 2Joint UFSCar-UNESP Graduate Program in Physiological Sciences, Brazil 3Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, 14049-900, Brazil.
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