Document Detail


Effect of a single bolus of intracoronary basic fibroblast growth factor on perfusion in an ischemic porcine model.
MedLine Citation:
PMID:  10375718     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Basic fibroblast growth factor (bFGF) has been shown to induce angiogenesis in various animal models, but the methods of administration used experimentally are not clinically feasible. The objective of this study was to determine whether a single intracoronary bolus injection of bFGF would improve coronary perfusion in a porcine ischemic model that mimics clinical chronic ischemia. A copper coil studded with gold was delivered into the proximal right coronary artery of juvenile Yorkshire pigs and deployed by interventional techniques. After a four-week interval for stenosis maturation, bFGF (100 micrograms) was administered by bolus injection into the left coronary artery in five animals, and vehicle alone was administered in four animals. Angiogenesis and change in right coronary perfusion area were assessed two weeks later by angiography, myocardial contrast echocardiography and immunohistochemistry. The right coronary perfusion area increased significantly after treatment in all but one of the animals that received bFGF but not in any of the controls. Intimal hyperplasia was not induced by bFGF. Capillary density determined histochemically was not different in the two groups. In conclusion, in a porcine ischemic model, bFGF administered by a single bolus intracoronary injection into the contralateral artery improved antegrade perfusion into the ischemic territory although without histological evidence of angiogenesis. This preliminary work merits further investigation.
Authors:
G P Devlin; S Fort; E Yu; R J Cusimano; K Wei; H Rakowski; J Butany; J A Richards; M J Sole; L Schwartz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Canadian journal of cardiology     Volume:  15     ISSN:  0828-282X     ISO Abbreviation:  Can J Cardiol     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-07-14     Completed Date:  1999-07-14     Revised Date:  2008-04-09    
Medline Journal Info:
Nlm Unique ID:  8510280     Medline TA:  Can J Cardiol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  676-82     Citation Subset:  IM    
Affiliation:
The Toronto Hospital, University of Toronto, Canada. devling@hwl.co.nz
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MeSH Terms
Descriptor/Qualifier:
Animals
Coronary Angiography
Coronary Disease / radiography
Disease Models, Animal
Echocardiography
Fibroblasts
Humans
Myocardial Ischemia* / therapy
Myocardial Reperfusion / methods*
Swine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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