Document Detail

Effect of simvastatin on restenosis after percutaneous transluminal angioplasty of femoropopliteal arterial obstruction.
MedLine Citation:
PMID:  11018199     Owner:  NLM     Status:  MEDLINE    
This retrospective observational intravascular ultrasound study evaluated whether simvastatin therapy limits lumen area reduction 1-year after percutaneous transluminal angioplasty (PTA) by reducing reactive plaque growth, reducing reactive vasoconstriction, or both. This study showed that plaque growth is a general response 1 year after PTA regardless of the use of simvastatin; simvastatin has the potential to induce positive vascular remodeling, thereby reducing the occurrence of restenosis.
T Hagenaars; E J Gussenhoven; M R van Sambeek; J W Jukema; S E Kranendonk; N Bom
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of cardiology     Volume:  86     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-11-01     Completed Date:  2000-11-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  774-6, A6     Citation Subset:  AIM; IM    
Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary*
Arterial Occlusive Diseases / drug therapy,  pathology,  therapy*,  ultrasonography
Chemotherapy, Adjuvant
Femoral Artery* / pathology,  ultrasonography
Follow-Up Studies
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Middle Aged
Popliteal Artery* / pathology,  ultrasonography
Retrospective Studies
Simvastatin / therapeutic use*
Ultrasonography, Interventional
Reg. No./Substance:
0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 79902-63-9/Simvastatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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