Document Detail

Effect of silymarin on chemical, functional, and morphological alterations of the liver. A double-blind controlled study.
MedLine Citation:
PMID:  6753109     Owner:  NLM     Status:  MEDLINE    
One hundred and six consecutive patients with liver disease were selected on the basis of elevated serum transaminase levels. The patients were randomly allocated into a group treated with silymarin (treated) and a group receiving placebo (controls). Ninety-seven patients complete the 4-week trial-47 treated and 50 controls. In general, the series represented a relatively slight acute and subacute liver disease, mostly induced by alcohol abuse. There was a statistically highly significantly greater decrease of S-SGPT (S-ALAT) and S-SGOT (S-ASAT) in the treated group than in controls. Serum total and conjugated bilirubin decreased more in the treated than in controls, but the differences were not statistically significant. BSP retention returned to normal significantly more often in the treated group. The mean percentage decrease of BSP was also markedly higher in the treated. Normalization of histological changes occurred significantly more often in the treated than in controls.
H A Salmi; S Sarna
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  17     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  1982 Jun 
Date Detail:
Created Date:  1982-12-16     Completed Date:  1982-12-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  517-21     Citation Subset:  IM    
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MeSH Terms
Alanine Transaminase / blood
Alkaline Phosphatase / blood
Aspartate Aminotransferases / blood
Clinical Enzyme Tests
Clinical Trials as Topic
Double-Blind Method
Flavonoids / therapeutic use*
Liver Diseases / diagnosis,  drug therapy*
Liver Diseases, Alcoholic / diagnosis,  drug therapy*
Liver Function Tests
Silymarin / therapeutic use*
Reg. No./Substance:
0/Flavonoids; 0/Silymarin; EC Aminotransferases; EC Transaminase; EC Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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