| Effect of silymarin on chemical, functional, and morphological alterations of the liver. A double-blind controlled study. | |
| | |
MedLine Citation:
|
PMID: 6753109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
One hundred and six consecutive patients with liver disease were selected on the basis of elevated serum transaminase levels. The patients were randomly allocated into a group treated with silymarin (treated) and a group receiving placebo (controls). Ninety-seven patients complete the 4-week trial-47 treated and 50 controls. In general, the series represented a relatively slight acute and subacute liver disease, mostly induced by alcohol abuse. There was a statistically highly significantly greater decrease of S-SGPT (S-ALAT) and S-SGOT (S-ASAT) in the treated group than in controls. Serum total and conjugated bilirubin decreased more in the treated than in controls, but the differences were not statistically significant. BSP retention returned to normal significantly more often in the treated group. The mean percentage decrease of BSP was also markedly higher in the treated. Normalization of histological changes occurred significantly more often in the treated than in controls. |
| | |
Authors:
|
H A Salmi; S Sarna |
Related Documents
:
|
21130329 - Success rate of anterior open-bite orthodontic-orthognathic surgical treatment. 15811769 - Usefulness of granular bcaa after hepatectomy for liver cancer complicated with liver c... 8171069 - The role of prostaglandins in hepatic resection. 18208439 - A new surgical technique for hepatic vein reconstruction in pediatric live donor liver ... 21232119 - Oral vitamin b12 for patients suspected of subtle cobalamin deficiency: a multicentre p... 15244209 - Terlipressin and albumin combination treatment in hepatorenal syndrome. 20556359 - Are commonly recommended dosages for vitamin d supplementation too low? vitamin d statu... 15799729 - Clinical outcomes of phacoemulsification cataract surgery in diabetes patients: visual ... 9798189 - A clinical evaluation of diclofenac-gentamicin combination eye drops in the control of ... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Scandinavian journal of gastroenterology Volume: 17 ISSN: 0036-5521 ISO Abbreviation: Scand. J. Gastroenterol. Publication Date: 1982 Jun |
Date Detail:
|
Created Date: 1982-12-16 Completed Date: 1982-12-16 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0060105 Medline TA: Scand J Gastroenterol Country: NORWAY |
Other Details:
|
Languages: eng Pagination: 517-21 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Alanine Transaminase / blood Alkaline Phosphatase / blood Aspartate Aminotransferases / blood Clinical Enzyme Tests Clinical Trials as Topic Double-Blind Method Flavonoids / therapeutic use* Humans Liver Diseases / diagnosis, drug therapy* Liver Diseases, Alcoholic / diagnosis, drug therapy* Liver Function Tests Male Silymarin / therapeutic use* |
| Chemical | |
Reg. No./Substance:
|
0/Flavonoids; 0/Silymarin; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase; EC 3.1.3.1/Alkaline Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The correlation between gastric emptying time and the response of GIP and enteroglucagon to oral glu...
Next Document: The chemotactic function of neutrophils in ulcerative colitis.