Document Detail

Effect of silymarin administration on TNF-α serum concentration in peritoneal dialysis patients.
MedLine Citation:
PMID:  21031623     Owner:  NLM     Status:  MEDLINE    
Chronic inflammation in dialysis patients increases the production of cytokines such as TNF-α, IL-1β and IFN- IFN-γ and there is evidence of a significant mortality rate in dialysis patients due to inflammation. Overproduction of inflammatory cytokines can induce complications such as atherosclerosis, malnutrition and anaemia, which are mostly resistant to erythropoietin treatment. Cardiovascular disease is the leading cause of death in haemodialysis patients and about half of the mortality is attributable to cardiovascular disease. Silymarin modulates the immune system by inhibition of neutrophil immigration, mast cell immobilization, prostaglandin production and leukotriene synthesis. Furthermore, silymarin suppresses the induction of TNF-α and it was hypothesized that silymarin could decrease the serum concentration of TNF-α in peritoneal dialysis patients, and thus treat anaemia. Fifteen peritoneal dialysis patients were enrolled in this study and serum levels of soluble TNF-α were measured using an enzyme-linked immunosorbant assay (ELISA) kit. Serum TNF-α was found to be decreased in some patients and in the response group, the haemoglobin concentration after 8 weeks of silymarin administration was increased significantly (p < 0.05). Based on the results of this study, it is suggested that silymarin may be useful in the treatment of inflammation for peritoneal dialysis patients.
Fatemeh Nazemian; Gholamreza Karimi; Mahdi Moatamedi; Somayeh Charkazi; Jamal Shamsara; Amir Hooshang Mohammadpour
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  24     ISSN:  1099-1573     ISO Abbreviation:  Phytother Res     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-29     Completed Date:  2011-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1654-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 John Wiley & Sons, Ltd.
Nephrology Ward, Department of Internal Medicine, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
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MeSH Terms
Enzyme-Linked Immunosorbent Assay
Hemoglobins / analysis
Inflammation / drug therapy*
Middle Aged
Peritoneal Dialysis*
Silymarin / therapeutic use*
Tumor Necrosis Factor-alpha / blood*,  drug effects
Reg. No./Substance:
0/Hemoglobins; 0/Silymarin; 0/Tumor Necrosis Factor-alpha

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