| Effect of silver nitrate on pregnancy termination in cynomolgus monkeys. | |
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MedLine Citation:
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PMID: 7250398 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of intrauterine injection of 1% silver nitrate on pregnancy was studied in 13 cynomolgus monkeys. The monkeys received, in a random manner, intrauterine injections of 1 ml of either 1% silver nitrate (n = 7) or 0.9% NaCl solution (n = 6) between days 27 and 43 of pregnancy. Silver nitrate injection resulted in vaginal bleeding, beginning 1 or 2 days after treatment, that lasted for an average of 5.3 days. In all of these cases, pregnancy was terminated. Injection of normal saline had variable sequelae, but four of six monkeys were delivered of healthy offspring. All of the silver nitrate-treated animals recycled and, after remating, two of the seven subsequently became pregnant again and were delivered of normal healthy infants. This study demonstrates the efficacy of intrauterine injection of 1% silver nitrate in terminating early pregnancy. |
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Authors:
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N H Dubin; T H Parmley; R T Cox; T M King |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Fertility and sterility Volume: 36 ISSN: 0015-0282 ISO Abbreviation: Fertil. Steril. Publication Date: 1981 Jul |
Date Detail:
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Created Date: 1981-09-22 Completed Date: 1981-09-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 106-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abortifacient Agents* Abortifacient Agents, Nonsteroidal* Abortion, Induced / methods* Animals Female Macaca fascicularis Pregnancy Pregnancy, Animal* Silver Nitrate / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Abortifacient Agents; 0/Abortifacient Agents, Nonsteroidal; 7761-88-8/Silver Nitrate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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