Document Detail


Effect of silver nitrate on pregnancy termination in cynomolgus monkeys.
MedLine Citation:
PMID:  7250398     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of intrauterine injection of 1% silver nitrate on pregnancy was studied in 13 cynomolgus monkeys. The monkeys received, in a random manner, intrauterine injections of 1 ml of either 1% silver nitrate (n = 7) or 0.9% NaCl solution (n = 6) between days 27 and 43 of pregnancy. Silver nitrate injection resulted in vaginal bleeding, beginning 1 or 2 days after treatment, that lasted for an average of 5.3 days. In all of these cases, pregnancy was terminated. Injection of normal saline had variable sequelae, but four of six monkeys were delivered of healthy offspring. All of the silver nitrate-treated animals recycled and, after remating, two of the seven subsequently became pregnant again and were delivered of normal healthy infants. This study demonstrates the efficacy of intrauterine injection of 1% silver nitrate in terminating early pregnancy.
Authors:
N H Dubin; T H Parmley; R T Cox; T M King
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Fertility and sterility     Volume:  36     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1981 Jul 
Date Detail:
Created Date:  1981-09-22     Completed Date:  1981-09-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  106-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Abortifacient Agents*
Abortifacient Agents, Nonsteroidal*
Abortion, Induced / methods*
Animals
Female
Macaca fascicularis
Pregnancy
Pregnancy, Animal*
Silver Nitrate / pharmacology*
Chemical
Reg. No./Substance:
0/Abortifacient Agents; 0/Abortifacient Agents, Nonsteroidal; 7761-88-8/Silver Nitrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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