Document Detail


Effect of silica on the pathogenic distinction between herpes simplex virus type 1 and 2 hepatitis in mice.
MedLine Citation:
PMID:  197016     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The role of macrophages in the difference in liver pathogenicity between herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in mice was investigated by selectively blocking the macrophage function of the mice by silica. Intravenous administration of 3 mg of silica 2 h before virus inoculation partially abolished the difference between the two virus types, as judged by macroscopic and microscopic examination of the livers and by virus isolation studies. Intraperitoneal inoculation of 50 mg of silical before virus seemed more effective in suppressing the macrophage function, since this treatment almost completely eliminated the difference in hepatotropism between HSV-1 and HSV-2 as assessed by the number and size of the lesions appearing in the liver. The final outcome of the infection, death from encephalitis, was, however, not influenced by macrophage blockade.
Authors:
S C Mogensen; H K Andersen
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Infection and immunity     Volume:  17     ISSN:  0019-9567     ISO Abbreviation:  Infect. Immun.     Publication Date:  1977 Aug 
Date Detail:
Created Date:  1977-10-14     Completed Date:  1977-10-14     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0246127     Medline TA:  Infect Immun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  274-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / microbiology
Female
Hepatitis, Animal / microbiology*,  pathology
Herpesviridae Infections / microbiology*,  pathology
Liver / pathology
Macrophages / drug effects*,  microbiology
Mice
Mice, Inbred Strains
Silicon Dioxide / pharmacology*
Simplexvirus / growth & development,  pathogenicity*
Spleen / microbiology
Virus Replication / drug effects
Chemical
Reg. No./Substance:
7631-86-9/Silicon Dioxide
Comments/Corrections

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