Document Detail

Effect of sildenafil on hypoxia-induced changes in pulmonary circulation and right ventricular function.
MedLine Citation:
PMID:  17851140     Owner:  NLM     Status:  MEDLINE    
Hypoxia leads to pulmonary vasoconstriction in healthy men. However, the consequences on right ventricular function are not known. The effects of hypoxia on systolic pulmonary artery pressure (sPAP) and right ventricular function index (TEI) were assessed by Doppler echocardiography. Fourteen members of a Mount Everest expedition were monitored during acute hypoxic challenge at sea level, environmental hypoxia exposure at altitudes of 3440 m and 5245 m and 2 weeks after return to sea level. Subjects received either placebo or 50mg sildenafil in a double-blind randomised cross-over design. Under normoxia at baseline, mean sPAP was 17.1(S.E.M. 1.3) mm Hg, and TEI was 0.13(0.004). Both increased during acute hypoxia: sPAP 29.6(2.6) mm Hg, and TEI 0.35(0.06) (each p<0.01). At 5245 m sPAP was 29.1(1.7) and TEI was 0.43(0.05) in the placebo group, while in the sildenafil group, both sPAP and TEI were reduced to 22(1.5) mm Hg and 0.23(0.03) (each p<0.005), respectively. We conclude that in healthy individuals, exposure to acute hypoxia and sojourns at high altitude result in a small but significant increase in sPAP accompanied by an impairment of right ventricular function. Sildenafil significantly decreases sPAP and improves right ventricular function.
Frank Reichenberger; Markus G Kohstall; Timon Seeger; Horst Olschewski; Friedrich Grimminger; Werner Seeger; Hossein A Ghofrani
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2007-07-27
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  159     ISSN:  1569-9048     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-22     Completed Date:  2008-02-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  196-201     Citation Subset:  IM    
Pulmonary Vascular Diseases Unit, University of Giessen Lung Center (UGLC), University Hospital Giessen, Germany.
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MeSH Terms
Anoxia / drug therapy*,  physiopathology*
Double-Blind Method
Echocardiography, Doppler / methods
Follow-Up Studies
Middle Aged
Mountaineering / physiology
Piperazines / therapeutic use*
Pulmonary Circulation / drug effects*
Purines / therapeutic use
Sulfones / therapeutic use*
Vasodilator Agents / therapeutic use*
Ventricular Function, Right / drug effects*
Reg. No./Substance:
0/Piperazines; 0/Purines; 0/Sulfones; 0/Vasodilator Agents; 139755-83-2/sildenafil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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