| Effect of sildenafil on clitoral blood flow and sexual response in postmenopausal women with orgasmic dysfunction. | |
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MedLine Citation:
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PMID: 18589423 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To analyze the effects of sildenafil citrate on clitoral blood flow and sexual response in postmenopausal women with orgasmic dysfunction. METHOD: In this randomized, double-blind, placebo-controlled trial 22 women received a 50-mg dose of sildenafil (n=11) or placebo (n=11) daily for 15 days. The Golombok Rust Inventory of Sexual Satisfaction (GRISS) was used for subjective evaluation of the sexual-response cycle. Clitoral blood flow was measured by color and pulse Doppler at baseline, after 1 hour of taking the first dose, and after 15 days of treatment. RESULTS: Blood flow was significantly more improved in the sildenafil than in the placebo group (P<0.05), and a positive correlation between Doppler values and GRISS scores was noted in the sildenafil group after only 15 days of treatment. CONCLUSION: Sildenafil may improve clitoral blood flow and increase the GRISS scores in postmenopausal women with orgasmic dysfunction. |
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Authors:
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Ana L Cavalcanti; Vicente R Bagnoli; Angela M Fonseca; Roberto A Pastore; Eduardo B Cardoso; Jucilene S Paixão; José M Soares; Fabrício Saad; Edmund C Baracat |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2008-06-26 |
Journal Detail:
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Title: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics Volume: 102 ISSN: 0020-7292 ISO Abbreviation: Int J Gynaecol Obstet Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-15 Completed Date: 2008-11-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0210174 Medline TA: Int J Gynaecol Obstet Country: Ireland |
Other Details:
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Languages: eng Pagination: 115-9 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of São Paulo, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Flow Velocity Clitoris / blood supply, drug effects*, physiology*, ultrasonography Double-Blind Method Female Humans Middle Aged Personal Satisfaction Piperazines / pharmacology* Postmenopause Purines / pharmacology Regional Blood Flow / drug effects Sexual Dysfunction, Physiological / physiopathology* Sexual Dysfunctions, Psychological / physiopathology* Sulfones / pharmacology* Ultrasonography, Doppler, Color Ultrasonography, Doppler, Pulsed Vasodilator Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Piperazines; 0/Purines; 0/Sulfones; 0/Vasodilator Agents; 139755-83-2/sildenafil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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