| Effect of signal strength on reproducibility of circumpapillary retinal nerve fiber layer thickness measurement and its classification by spectral-domain optical coherence tomography. | |
| | |
MedLine Citation:
|
PMID: 21559911 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
PURPOSE: To assess the effect of signal strength (SS) on the reproducibility of circumpapillary retinal nerve fiber layer (cpRNFL) thickness measurement (measurement agreement) and its color-coded classification (classification agreement) by Cirrus spectral-domain optical coherence tomography (OCT). METHODS: Seven hundred and eighty-nine participants, consecutively enrolled from December 2009 to August 2010, underwent two repeated Cirrus OCT scans to measure cpRNFL thickness (optic disc cube 200 × 200). Intraclass correlation (ICC) and linear-weighted kappa coefficient (κ) were calculated as indicators for cpRNFL measurement and classification agreement. The difference in cpRNFL thickness measurements between repeated OCT scans (inter-scan measurement difference) was correlated with mean SS, SS change or difference between repeated OCT scans (inter-scan SS difference), and average cpRNFL thickness. RESULTS: Mean SS was negatively correlated with inter-scan SS difference and was positively correlated with the inter-scan measurement difference. Repeated scans with SS change (inter-scan SS difference = 1 or 2) showed larger variability than scans without SS change (inter-scan SS difference = 0) in total average cpRNFL and all quadrant maps except for the nasal quadrant. Multivariate analysis revealed that inter-scan measurement differences increased in subjects with thinner cpRNFL thicknesses and in scans with lower mean SS and higher inter-scan SS differences. Measurement agreement (ICC) in groups with larger inter-scan SS differences (=2) was lower than those with smaller inter-scan SS differences (=0 or 1) in their average cpRNFL and inferior quadrant maps. Classification agreement (κ) in groups with larger inter-scan SS differences (=2) was lower than those with smaller inter-scan SS differences (=0 or 1) in their average cpRNFL and quadrant maps (superior and inferior quadrant) although statistically not significant. CONCLUSIONS: Special attention should be paid when comparing the cpRNFL thickness measurement and color-coded classification of 2 or more Cirrus OCT scans as the agreements may be susceptible to SS differences. |
| | |
Authors:
|
Ji Hyun Kim; Na Rae Kim; Hyunjoong Kim; Eun Suk Lee; Gong Je Seong; Chan Yun Kim |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-5-11 |
Journal Detail:
|
Title: Japanese journal of ophthalmology Volume: - ISSN: 1613-2246 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-5-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0044652 Medline TA: Jpn J Ophthalmol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Ophthalmology, Institute of Vision Research, Yonsei University College of Medicine, CPO Box 8044, Seoul, 120-752, Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Trabeculotomy combined with phacoemulsification, intraocular lens implantation and sinusotomy for ex...
Next Document: Nishida's procedure combined with medial rectus recession for large-angle esotropia in Duane syndrom...