Document Detail


Effect of short-term treatment with recombinant human growth hormone on lipids and lipoproteins in women and men without growth hormone disturbances.
MedLine Citation:
PMID:  7783656     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of recombinant human growth hormone (rHGH) on cholesterol, high- and low-density lipoprotein (HDL and LDL) cholesterol, triglycerides (TG), apolipoprotein (apo) B, apo A-I, and lipoprotein(a) [Lp(a)] was studied in 40 postmenopausal women treated with 0.05, 0.1, or 0.2 IU/kg/d rHGH or placebo for 7 days. Cholesterol, LDL cholesterol, and HDL cholesterol decreased in a dose-dependent manner (P = .001, P = .001, and P = .003, respectively), whereas apo B decreased insignificantly (P = .15). Apo A-I decreased significantly only among women treated with rHGH at a dose of 0.1 IU/kg/d (P = .03). When all rHGH-treated women were grouped together, Lp(a) increased (P = .001). We also studied 20 young men treated with either 0.2 IU/kg/d rHGH or placebo. As in women, cholesterol and apo B decreased P = .005 and P = .02, respectively), whereas Lp(a) increased (P = .05). There was no detectable effect of rHGH on TG concentrations in men. As in women, there was no significant effect of 0.2 IU/kg/d rHGH on apo A-I concentrations. All lipid and lipoprotein measures reached pretreatment levels during the first week after treatment was stopped, except Lp(a), which remained elevated 2 weeks after rHGH cessation.
Authors:
P S Hansen; M Kassem; K Brixen; I C Klausen; L Mosekilde; O Faergeman
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  44     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-07-14     Completed Date:  1995-07-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  725-9     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine and Cardiology A, Aarhus University Hospital, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Aged
Cholesterol / blood
Dose-Response Relationship, Drug
Double-Blind Method
Female
Growth Hormone / blood,  pharmacology*
Humans
Lipids / blood*
Lipoprotein(a) / blood
Lipoproteins / blood*
Male
Middle Aged
Recombinant Proteins
Reference Values
Sex Characteristics*
Time Factors
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Lipids; 0/Lipoprotein(a); 0/Lipoproteins; 0/Recombinant Proteins; 0/Triglycerides; 57-88-5/Cholesterol; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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