Document Detail

Effect of short-term medroxyprogesterone acetate on left ventricular mass: role of insulin-like growth factor-1.
MedLine Citation:
PMID:  10535399     Owner:  NLM     Status:  MEDLINE    
Previous studies using 17beta-estradiol and medroxyprogesterone acetate (MPA) have shown that hormone replacement therapy (HRT) increases left ventricular mass (LVM). To determine if insulin-like growth factor-1 (IGF-1) is associated with the increase in LVM, we measured IGF-1 and IGF-binding protein-3 (IGFBP-3) levels in 19 postmenopausal women before and after 8 weeks of oral treatment with MPA 5 mg/d. LVM was measured by two-dimensional echocardiography. Changes in IGF-1, IGFBP-3, and LVM from baseline were analyzed by paired ttest. Regression analysis was used to determine if changes in the IGF-1 axis with MPA treatment affect the increase in LVM. LVM increased 4.4% during the study (P = .006 vbaseline). IGF-1 increased 17% with MPA (P = .008), whereas IGFBP-3 did not change. The IGF-1/IGFBP-3 ratio increased 16.8% (P = .0003). Regression analysis of LVM with IGF-1, IGFBP-3, and the IGF-1/IGFBP-3 ratio suggested that IGF-1 during MPA therapy explains 2.4% and the IGF-1/IGFBP-3 ratio explains 3.2% of the variation in LVM. There was no effect of IGFBP-3 on LVM. Most of the variation in LVM with MPA (90.5%) was explained by baseline LVM. The IGF-1/IGFBP-3 ratio on MPA treatment was inversely related to the change in LVM: women with a lower LVM at baseline had the greatest increase in LVM with MPA. These findings suggest that MPA increases IGF-1 and LVM. Because the increase in IGF-1 with MPA treatment explains a fraction of the increase in LVM, other mechanisms must also be operative.
C K Sites; M D Tischler; C J Rosen; M O'Connell; J Niggel; T Ashikaga
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  48     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-11-05     Completed Date:  1999-11-05     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1328-31     Citation Subset:  IM    
Department of Obstetrics and Gynecology, The University of Vermont College of Medicine, Burlington 05405, USA.
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MeSH Terms
Echocardiography / drug effects
Heart Ventricles / anatomy & histology*,  drug effects
Insulin-Like Growth Factor Binding Protein 3 / blood
Insulin-Like Growth Factor I / metabolism
Medroxyprogesterone Acetate / pharmacology*
Middle Aged
Postmenopause / physiology*
Progesterone Congeners / pharmacology*
Regression Analysis
Grant Support
Reg. No./Substance:
0/Insulin-Like Growth Factor Binding Protein 3; 0/Progesterone Congeners; 67763-96-6/Insulin-Like Growth Factor I; 71-58-9/Medroxyprogesterone Acetate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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