| Effect of short-term maximal exercise on BNP plasma levels in healthy individuals. | |
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MedLine Citation:
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PMID: 19929142 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many studies documented the relationship between elevated plasma concentrations of natriuretic peptides and cardiovascular diseases, especially heart failure. However, it is still uncertain whether physical exercise leads to a significant release of natriuretic peptide in healthy subjects. The aim of this study was to determine the effect of maximal physical activity on plasma BNP concentrations in healthy individuals within 3 hours after the short-term exercise. BNP plasma concentrations were measured in 15 healthy volunteers before, immediately after as well as 1 hour and 3 hours after bicycle spiroergometry. Maximal workload and exercise capacity were assessed in watts, watt-seconds, metabolic equivalents and VO(2max). Mean BNP plasma levels before, immediately after, 1 hour and 3 hours post-exercise were 19.4+/-2.5; 30.6+/-4.7; 17.9+/-2.5 and 18.7+/-3.1 pg/ml, respectively. The increase of BNP concentrations immediately after exercise was statistically significant (p=0.0017) compared to baseline values. We did not find any correlation between the post-exercise increase of BNP levels and age, body mass index, maximal workload or exercise capacity. In conclusion, short-term maximal physical exercise in healthy individuals led to a fast and transient rise of plasma BNP concentrations, which remained well within normal range and far below the cut-off value for heart failure (100 pg/ml). |
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Authors:
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J Krupicka; T Janota; Z Kasalová; J Hradec |
Publication Detail:
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Type: Journal Article Date: 2009-11-20 |
Journal Detail:
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Title: Physiological research / Academia Scientiarum Bohemoslovaca Volume: 59 ISSN: 0862-8408 ISO Abbreviation: Physiol Res Publication Date: 2010 |
Date Detail:
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Created Date: 2010-09-27 Completed Date: 2010-10-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9112413 Medline TA: Physiol Res Country: Czech Republic |
Other Details:
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Languages: eng Pagination: 625-8 Citation Subset: IM |
Affiliation:
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Third Department of Internal Medicine, First School of Medicine and University General Hospital, Charles University in Prague, Czech Republic. j.krupicka@centrum.cz |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / blood Blood Pressure Exercise* Female Heart Rate Humans Male Middle Aged Natriuretic Peptide, Brain / blood* Oxygen Consumption Respiratory Mechanics Time Factors Up-Regulation |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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