Document Detail

Effect of short-term levamisole therapy on delayed hypersensitivity.
MedLine Citation:
PMID:  6985836     Owner:  NLM     Status:  MEDLINE    
A randomized trial of short-term Levamisole treatment was undertaken in a cancer population unresponsive to dinitrochlorobenzene (DNCB) to determine whether this agent increased delayed hypersensitivity. Of 100 patients entered, 50 received Levamisole (150 mg daily x 3) during DNCB challenge. The other 50 patients were challenged but not given the drug. The conversion rate to DNCB+ was 20% (10/50) for those treated and 12% (6/50) for controls. The difference is not significant. When all 100 patients were considered there was a statistically significant inverse relationship between extent of disease and the incidence of conversion to a DNCB reactive state. Levamisole as given does not appear to have a major influence on delayed cutaneous hypersensitivity.
Y Hirshaut; C M Pinsky; I Frydecka; H J Wanebo; S Passe; V Miké; H F Oettgen
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer     Volume:  45     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1980 Jan 
Date Detail:
Created Date:  1980-03-27     Completed Date:  1980-03-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  362-6     Citation Subset:  AIM; IM    
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MeSH Terms
Clinical Trials as Topic
Dinitrochlorobenzene / immunology
Hypersensitivity, Delayed*
Immunity, Cellular / drug effects
Intradermal Tests
Levamisole / administration & dosage,  therapeutic use*
Middle Aged
Neoplasms / drug therapy*,  immunology
Time Factors
Reg. No./Substance:
14769-73-4/Levamisole; 97-00-7/Dinitrochlorobenzene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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