| Effect of short-term hyperthyroxinemia on vitamin D metabolism in congenital hypothyroidism. | |
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MedLine Citation:
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PMID: 8406326 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The circulating concentrations of vitamin D metabolites were measured in nine children (four to ten years of age) with congenital hypothyroidism on L-thyroxine therapy, before and after a short term increase (33%) in dosage. The concentrations of 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D were not altered, but the concentration of 1,25 dihydroxyvitamin D was significantly higher in the serum of the children after three weeks of hyperthyroxinemia. This was associated with an increase in urinary calcium excretion. The increases in serum concentration of 1,25 dihydroxyvitamin D cannot be explained by differences in serum levels of calcium, phosphorus or parathyroid hormone. These findings differ from data obtained in adults. |
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Authors:
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J Laufer; D Noff; S Orda; J Sack |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme Volume: 25 ISSN: 0018-5043 ISO Abbreviation: Horm. Metab. Res. Publication Date: 1993 Jul |
Date Detail:
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Created Date: 1993-11-08 Completed Date: 1993-11-08 Revised Date: 2009-02-19 |
Medline Journal Info:
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Nlm Unique ID: 0177722 Medline TA: Horm Metab Res Country: GERMANY |
Other Details:
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Languages: eng Pagination: 386-8 Citation Subset: IM |
Affiliation:
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Pediatric Nephrology Unit, Chaim Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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25-Hydroxyvitamin D 2
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blood Calcium / blood, urine Child Child, Preschool Congenital Hypothyroidism Ergocalciferols / blood Humans Hypothyroidism / drug therapy, metabolism* Thyroxine / blood*, therapeutic use Vitamin D / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Ergocalciferols; 1406-16-2/Vitamin D; 21343-40-8/25-Hydroxyvitamin D 2; 55248-15-2/1,25-dihydroxyergocalciferol; 7440-70-2/Calcium; 7488-70-2/Thyroxine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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