Document Detail


Effect of a short-term graded exhaustive exercise on the susceptibility of serum lipids to oxidation.
MedLine Citation:
PMID:  16237618     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of our study was to evaluate the effect of short-term intensive exercise on the susceptibility of serum lipids to ex-vivo peroxidation. We assessed the association between aerobic capacity, serum composition, and serum lipid oxidizability as well as the association between aerobic capacity and the effect of short-term maximal exercise on the kinetics of ex-vivo copper-induced peroxidation of serum lipids. The study involved 30 healthy male volunteers (age 22-39 years, BMI 19.4-29.8). Following 12-hr fasting, blood was withdrawn for determination of blood lipids, LDL, HDL, and TG, and Vitamin E, and for oxidizability assay of the serum lipids. Subsequently, each volunteer underwent an incremental all-out cardiopulmonary exercise stress test (CPET), performed on a motor-driven treadmill (Quinton Q65, USA). The test protocol was a modified Balke protocol. The results of this test were expressed in terms of mass-dependent maximal oxygen uptake (VO2max, ml.kg(-1).min (-1)) and of ventilatory anaerobic threshold (VAT, ml.kg(-1).min(-1)). Immediately after exercise, blood was re-drawn for the determination of serum Vitamin E and for ex-vivo oxidizibility assay, expressed in terms of maximal absorption of oxidation products (OD(max), absorbance units), maximal rate of their production (V(max), OD min(-1)) and the time at which the rate was maximal (t(max), min). Maximal graded exercise had no significant effect on the susceptibility of serum lipids to peroxidation as measured by OD(max) (p = 0.38 at 245 nm, and 0.27 at 268 nm),V(max) (p = 0.34 at 245 nm, and 0.49 at 268 nm) and t(max) (p = 0.17 at 245 nm, and 0.07 at 268 nm). Also no effect was found on the concentration of serum Vitamin E (p = 0.39). Aerobic capacity was not associated either with the susceptibility of serum lipids to ex-vivo peroxidation or with serum Vitamin E concentration. The present findings indicate that a short graded maximal exercise, lasting 8-12 min, is not sufficient to increase the susceptibility of the serum lipids to peroxidation. Thus it may be assumed that the antioxidant capacity of most healthy subjects provides proper protection from a short exhaustive exercise challenge. Also, aerobic capacity in the range represented by our subjects does not seem to influence the susceptibility of serum lipids to peroxidation.
Authors:
A Dayan; A Rotstein; I Pinchuk; A Vodovicz; Z Lencovski; D Lichtenberg; O Inbar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of sports medicine     Volume:  26     ISSN:  0172-4622     ISO Abbreviation:  Int J Sports Med     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-20     Completed Date:  2006-02-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008349     Medline TA:  Int J Sports Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  732-8     Citation Subset:  IM    
Affiliation:
Department of Physiology and Pharmacology, Tel-Aviv University, Sackler School of Medicine, Tel-Aviv, Israel.
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MeSH Terms
Descriptor/Qualifier:
Adult
Exercise / physiology*
Humans
Lipid Peroxidation / physiology*
Oxygen Consumption
Physical Fitness
Time Factors
Vitamin E / blood
Chemical
Reg. No./Substance:
1406-18-4/Vitamin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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