Document Detail


Effect of short-term exposure to chlorpyrifos on developmental parameters and biochemical biomarkers in Chironomus riparius Meigen.
MedLine Citation:
PMID:  11534949     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chironomus riparius Meigen were exposed to sediment spiked with 0, 0.01, 0.05, and 0.10 mg chlorpyrifos/kg dry sediment for 48 h as late third-instar larvae. Acetylcholinesterase activity, glutathione-S-transferase activity, burrowing behavior, emergence time, and adult dry weight were measured to determine which were the most sensitive biomarkers of exposure and effect for short-term sublethal exposures. There was a significant drop in acetylcholinesterase activity at the two highest concentrations, but no effect on glutathione-S-transferase activity. Behavioral and life history biomarkers were sensitive only to the highest concentration of chlorpyrifos. The association of life history changes (female weight and male emergence times) with a significant inhibition of acetylcholinesterase activity suggests that this can be used as a biomarker of exposure and effect.
Authors:
A Callaghan; G Hirthe; T Fisher; M Crane
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Ecotoxicology and environmental safety     Volume:  50     ISSN:  0147-6513     ISO Abbreviation:  Ecotoxicol. Environ. Saf.     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-09-05     Completed Date:  2001-12-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7805381     Medline TA:  Ecotoxicol Environ Saf     Country:  United States    
Other Details:
Languages:  eng     Pagination:  19-24     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Academic Press.
Affiliation:
School of Animal & Microbial Sciences, The University of Reading, Whiteknights, Reading RG6 6AJ, United Kingdom. A.Callaghan@reading.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Acetylcholinesterase / drug effects,  metabolism*
Animals
Behavior, Animal / drug effects
Biological Markers / analysis
Chironomidae / drug effects,  growth & development*
Chlorpyrifos / adverse effects*
Geologic Sediments
Glutathione Transferase / drug effects,  metabolism*
Insecticides / adverse effects*
Larva / drug effects,  growth & development
Molting / drug effects
Reproduction / drug effects
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Insecticides; 2921-88-2/Chlorpyrifos; EC 2.5.1.18/Glutathione Transferase; EC 3.1.1.7/Acetylcholinesterase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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