| Effect of short-term exercise training on angiogenic growth factor gene responses in rats. | |
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MedLine Citation:
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PMID: 11247917 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated whether 1) 5 days of exercise training would reduce the acute exercise-induced increase in skeletal muscle growth factor gene expression; and 2) reductions in the increase in growth factor gene expression in response to short-term exercise training would be coincident with increases in skeletal muscle oxidative potential. Female Wistar rats were used. Six groups (rest; exercise for 1-5 consecutive days) were used to measure the growth factor response through the early phases of an exercise training program. Vascular endothelial growth factor (VEGF), transforming growth factor-beta1 (TGF-beta1), and basic fibroblast growth factor (bFGF) mRNA were analyzed from the left gastrocnemius by quantitative Northern blot. Citrate synthase activity was analyzed from the right gastrocnemius. VEGF and TGF-beta1 mRNA increased after each of 5 days of exercise training, whereas exercise on any day did not increase bFGF mRNA. On day 1, the VEGF mRNA response was significantly greater than on days 2-5. However, the reduced increase in VEGF mRNA observed on days 2-5 was not coincident with increases in citrate synthase activity. These findings suggest that, in skeletal muscle, 1) VEGF and TGF-beta1 mRNA are increased through 5 days of exercise training and 2) the reduced exercise-induced increase in VEGF mRNA responses on days 2-5 does not result from increases in oxidative potential. |
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Authors:
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T P Gavin; P D Wagner |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 90 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2001 Apr |
Date Detail:
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Created Date: 2001-03-15 Completed Date: 2001-05-31 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 1219-26 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of California San Diego, La Jolla, California 92093-0623, USA. gavint@mail.ecu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Citrate (si)-Synthase / biosynthesis Endothelial Growth Factors / biosynthesis, genetics* Female Fibroblast Growth Factors / biosynthesis, genetics* Gene Expression Regulation Lymphokines / biosynthesis, genetics* Oxidation-Reduction Physical Conditioning, Animal / physiology* RNA, Messenger / biosynthesis Rats Rats, Wistar Transforming Growth Factor beta / biosynthesis, genetics* Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors |
| Grant Support | |
ID/Acronym/Agency:
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HL-09624/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Endothelial Growth Factors; 0/Lymphokines; 0/RNA, Messenger; 0/Transforming Growth Factor beta; 0/Vascular Endothelial Growth Factor A; 0/Vascular Endothelial Growth Factors; 62031-54-3/Fibroblast Growth Factors; EC 2.3.3.1/Citrate (si)-Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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