Document Detail

Effect of short-term essential amino acid-containing dialysate in young children on CAPD.
MedLine Citation:
PMID:  2049429     Owner:  NLM     Status:  MEDLINE    
In young children on CAPD, hypoproteinemia and malnutrition are often observed. We used essential amino acid-containing dialysate (EAAD) to assess short-term effectiveness on serum amino acid concentrations in young children undergoing CAPD. EAAD consisted of a 540 ml, 1.5% glucose-containing dialysate and 100 ml of 7.4% essential amino acid (EAA) solution. Aside from methionine, all serum EAA rose during the 6 hour peritoneal dialysis cycle using EAAD, peaking at about 200% of pre-treatment level one hour after start of treatment. They then returned to near pre-treatment levels at the end of the cycle. However, serum methionine increased 680% of pre-treatment level, one hour after start and 390% at the end of the cycle. In the serum non-EAA tyrosine, which showed low levels in patients with chronic renal failure, increased after EAAD treatment. Other non-EAA, most of which showed increased levels in patients with chronic renal failure, decreased after EAAD treatment. These changes in serum amino acids suggest that EAA, absorbed from EAAD, may have increased uptake of non-EAA in protein synthesis. This may improve the nutritional status of young children on CAPD.
M Honda; Y Kamiyama; O Hasegawa; K Hoshinaga; O Ogawa; T Kawamura; H Ito
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis     Volume:  11     ISSN:  0896-8608     ISO Abbreviation:  Perit Dial Int     Publication Date:  1991  
Date Detail:
Created Date:  1991-07-22     Completed Date:  1991-07-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8904033     Medline TA:  Perit Dial Int     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  76-80     Citation Subset:  IM    
Department of Pediatric Nephrology and Urology, Tokyo Metropolitan Children's Hospital, Japan.
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MeSH Terms
Amino Acids, Essential / administration & dosage*,  blood
Child, Preschool
Dialysis Solutions / administration & dosage*
Dietary Proteins / administration & dosage
Energy Intake
Methionine / blood
Nutrition Disorders / prevention & control
Nutritional Status
Peritoneal Dialysis, Continuous Ambulatory*
Reg. No./Substance:
0/Amino Acids, Essential; 0/Dialysis Solutions; 0/Dietary Proteins; 63-68-3/Methionine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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