Document Detail


Effect of short-term endurance training on exercise capacity, haemodynamics and atrial natriuretic peptide secretion in heart transplant recipients.
MedLine Citation:
PMID:  8781855     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Exercise tolerance of heart transplant patients is often limited. Central and peripheral factors have been proposed to explain such exercise limitation but, to date, the leading factors remain to be determined. We examined how a short-term endurance exercise training programme may improve exercise capacity after heart transplantation, and whether atrial natriuretic peptide (ANP) release may contribute to the beneficial effects of exercise training by minimizing ischaemia and/or cardiac and circulatory congestion through its vasodilatation and haemoconcentration properties. Seven heart transplant recipients performed a square-wave endurance exercise test before and after 6 weeks of supervised training, while monitoring haemodynamic parameters, ANP and catecholamine concentrations. After training, the maximal tolerated power and the total mechanical work load increased from 130.4 (SEM 6.5) to 150.0 (SEM 6.0) W (P < 0.05) and from 2.05 (SEM 0.1) to 3.58 (SEM 0.14) kJ.kg-1 (P < 0.001). Resting heart rate decreased from 100.0 (SEM 3.4) to 92.4 (SEM 3.5) beats.min-1 (P < 0.05) but resting and exercise induced increases in cardiac output, stroke volume, right atrial, pulmonary capillary wedge, systemic and pulmonary artery pressures were not significantly changed by training. Exercise-induced decrease of systemic vascular resistance was similar before and after training. After training arterio-venous differences in oxygen content were similar but maximal lactate concentrations decreased from 6.20 (SEM 0.55) to 4.88 (SEM 0.6) mmol.l-1 (P < 0.05) during exercise. Similarly, maximal exercise noradrenaline concentration tended to decrease from 2060 (SEM 327) to 1168 (SEM 227) pg.ml-1. A significant correlation was observed between lactate and catecholamines concentrations. The ANP concentration at rest and the exercise-induced ANP concentration did not change throughout the experiment [104.8 (SEM 13.1) pg.ml-1 vs 116.0 (SEM 13.5) pg.ml-1 and 200.0 (SEM 23.0) pg.ml-1 vs 206.5 (SEM 25.9) pg.ml-1, respectively]. The results of this study suggested that the significant improvement in exercise capacity observed after this short-term endurance training period may have arisen mainly through peripheral mechanisms, associated with the possible decrease in plasma catecholamine concentrations and reversal of muscle deconditioning and/or prednisone-induced myopathy.
Authors:
B Geny; J Saini; B Mettauer; E Lampert; F Piquard; M Follenius; E Epailly; B Schnedecker; B Eisenmann; P Haberey; J Lonsdorfer
Related Documents :
12019955 - Exercise-induced changes in atrial peptides in relation to neuroendocrine responses and...
1666875 - Norepinephrine and atp are synergistic in the mouse vas deferens preparation.
8226475 - Relationship between arterial and portal vein immunoreactive glucagon during exercise.
12512745 - Influence of training habits on exercise-induced changes in plasma atrial and brain nat...
1394755 - Carbon dioxide absorption and gas exchange during pelvic laparoscopy.
11828245 - Effects of creatine supplementation on muscle power, endurance, and sprint performance.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of applied physiology and occupational physiology     Volume:  73     ISSN:  0301-5548     ISO Abbreviation:  Eur J Appl Physiol Occup Physiol     Publication Date:  1996  
Date Detail:
Created Date:  1996-11-01     Completed Date:  1996-11-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0410266     Medline TA:  Eur J Appl Physiol Occup Physiol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  259-66     Citation Subset:  IM; S    
Affiliation:
Service d'Explorations, Fonctionnelles Respiratoires et de l'Exercise, Faculté de Médecine, Université Louis Pasteur, Strasbourg, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Atrial Natriuretic Factor / secretion*
Blood Pressure
Epinephrine / blood
Exercise / physiology*
Female
Heart Rate
Heart Transplantation*
Hemodynamics*
Humans
Hydrogen-Ion Concentration
Lactic Acid / blood
Male
Middle Aged
Norepinephrine / blood
Physical Endurance*
Pulmonary Wedge Pressure
Stroke Volume
Vascular Resistance
Vasodilation
Chemical
Reg. No./Substance:
50-21-5/Lactic Acid; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Granulocyte chemiluminescence response to serum opsonized zymosan particles ex vivo during long-term...
Next Document:  Short-term changes in 10-km race pace aerobic demand and gait mechanics following a bout of high-int...