Document Detail

Effect of a short, heavy exposure to lead dust upon blood lead level, erythrocyte delta-aminolevulinic acid dehydratase activity and urinary excretion of lead delta-aminolevulinic acid coproporphyrin. Results of a 6-month follow-up of two male subjects.
MedLine Citation:
PMID:  788149     Owner:  NLM     Status:  MEDLINE    
During 1 h two healthy volunteers, not earlier exposed occupationally to lead, inhaled about 100 mg of lead as a mixture of lead oxides and lead sulfate. Maximum blood lead (PbB) concentrations of about 0.5 mg/1 and minimum blood cell delta-aminolevulinic acid dehydratase activities (ALAD) (6% of the preexposure values) were observed within 38 h after exposure. PbB and ALAD returned to preexposure levels after about 300 and 150 days. A highly significant correlation between ALAD and PbB was seen even at lead levels in the range 0.1-0.2 mg/1. Delta-aminolevulinic acid, coproporphyrin and lead in the urine (ALAU, CPU, and PbU, respectively) increased. The peak levels occurred after about 15 h for ALAU and CPU and after about 24 h for PbU. There was a very good correlation between log PbU and lin PbB. ALAU increased already at PbB levels of about 0.3 mg/1.
A Schütz; S Skerfving
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Scandinavian journal of work, environment & health     Volume:  2     ISSN:  0355-3140     ISO Abbreviation:  Scand J Work Environ Health     Publication Date:  1976 Sep 
Date Detail:
Created Date:  1976-12-03     Completed Date:  1976-12-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7511540     Medline TA:  Scand J Work Environ Health     Country:  FINLAND    
Other Details:
Languages:  eng     Pagination:  176-84     Citation Subset:  IM    
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MeSH Terms
Aminolevulinic Acid / metabolism,  urine
Clinical Trials as Topic
Coproporphyrins / urine
Environment, Controlled
Environmental Exposure
Follow-Up Studies
Lead / blood,  metabolism*,  urine
Porphobilinogen Synthase / blood
Reg. No./Substance:
0/Coproporphyrins; 106-60-5/Aminolevulinic Acid; 7439-92-1/Lead; EC Synthase

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