| Effect of a short, heavy exposure to lead dust upon blood lead level, erythrocyte delta-aminolevulinic acid dehydratase activity and urinary excretion of lead delta-aminolevulinic acid coproporphyrin. Results of a 6-month follow-up of two male subjects. | |
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MedLine Citation:
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PMID: 788149 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During 1 h two healthy volunteers, not earlier exposed occupationally to lead, inhaled about 100 mg of lead as a mixture of lead oxides and lead sulfate. Maximum blood lead (PbB) concentrations of about 0.5 mg/1 and minimum blood cell delta-aminolevulinic acid dehydratase activities (ALAD) (6% of the preexposure values) were observed within 38 h after exposure. PbB and ALAD returned to preexposure levels after about 300 and 150 days. A highly significant correlation between ALAD and PbB was seen even at lead levels in the range 0.1-0.2 mg/1. Delta-aminolevulinic acid, coproporphyrin and lead in the urine (ALAU, CPU, and PbU, respectively) increased. The peak levels occurred after about 15 h for ALAU and CPU and after about 24 h for PbU. There was a very good correlation between log PbU and lin PbB. ALAU increased already at PbB levels of about 0.3 mg/1. |
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Authors:
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A Schütz; S Skerfving |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Scandinavian journal of work, environment & health Volume: 2 ISSN: 0355-3140 ISO Abbreviation: Scand J Work Environ Health Publication Date: 1976 Sep |
Date Detail:
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Created Date: 1976-12-03 Completed Date: 1976-12-03 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7511540 Medline TA: Scand J Work Environ Health Country: FINLAND |
Other Details:
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Languages: eng Pagination: 176-84 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aminolevulinic Acid / metabolism, urine Clinical Trials as Topic Coproporphyrins / urine Environment, Controlled Environmental Exposure Follow-Up Studies Humans Lead / blood, metabolism*, urine Male Porphobilinogen Synthase / blood |
| Chemical | |
Reg. No./Substance:
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0/Coproporphyrins; 106-60-5/Aminolevulinic Acid; 7439-92-1/Lead; EC 4.2.1.24/Porphobilinogen Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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