Document Detail

Effect of shear mixing on in vitro drug release of capsule formulations containing lubricants.
MedLine Citation:
PMID:  903855     Owner:  NLM     Status:  MEDLINE    
The influence of shear mixing on the in vitro dissolution properties of several experimental capsule formulations containing lubricants was investigated. The studies were carried out in 2.8-liter laboratory V-blender equipped with a high-speed intensifier bar, using nitrofurantoin and procainamide hydrochloride as active drugs, powdered lactose and starch as excipients, and magnesium stearate and magnesium lauryl sulfate as lubricants. These studies revealed a pronounced inhibitory effect on drug dissolution due to shear in powder mixtures containing magnesium stearate; even at the maximum lubricant level of only 2%, high mixing markedly altered the in vitro dissolution rate. In systems with magnesium lauryl sulfate, the shear effect was less pronounced (nitrofurantoin blends) or absent (procainamide hydrochloride blends). The poor dissolution characteristics noted with magnesium stearate--shear combinations seem to result from the formation of a hydrophobic film around the powder mass, preventing wetting and deaggregation.
K S Murthy; J C Samyn
Related Documents :
12850355 - Maternal immunisation in developing countries.
3392705 - Propetamphos: a comparison of three formulations in preventing blowfly strike in sheep.
9210845 - Searching for preventable causes of infant mortality in texas.
21087075 - Changing costs and the impact on rsv prophylaxis.
18587695 - Reproduction in upheaval: ethnic-specific fertility responses to societal turbulence in...
14712945 - Admissions to neonatal intensive care unit following pregnancies complicated by gestati...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  66     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1977 Sep 
Date Detail:
Created Date:  1977-11-25     Completed Date:  1977-11-25     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1215-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Drug Compounding / methods*
Time Factors
Reg. No./Substance:
0/Capsules; 0/Excipients; 67-20-9/Nitrofurantoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Interaction between rod and cone signals studied with temporal sine wave stimulation.
Next Document:  High-pressure liquid chromatographic analysis of methotrexate in presence of its degradation product...