Document Detail


Effect of shear mixing on in vitro drug release of capsule formulations containing lubricants.
MedLine Citation:
PMID:  903855     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The influence of shear mixing on the in vitro dissolution properties of several experimental capsule formulations containing lubricants was investigated. The studies were carried out in 2.8-liter laboratory V-blender equipped with a high-speed intensifier bar, using nitrofurantoin and procainamide hydrochloride as active drugs, powdered lactose and starch as excipients, and magnesium stearate and magnesium lauryl sulfate as lubricants. These studies revealed a pronounced inhibitory effect on drug dissolution due to shear in powder mixtures containing magnesium stearate; even at the maximum lubricant level of only 2%, high mixing markedly altered the in vitro dissolution rate. In systems with magnesium lauryl sulfate, the shear effect was less pronounced (nitrofurantoin blends) or absent (procainamide hydrochloride blends). The poor dissolution characteristics noted with magnesium stearate--shear combinations seem to result from the formation of a hydrophobic film around the powder mass, preventing wetting and deaggregation.
Authors:
K S Murthy; J C Samyn
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  66     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1977 Sep 
Date Detail:
Created Date:  1977-11-25     Completed Date:  1977-11-25     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1215-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Capsules*
Drug Compounding / methods*
Excipients
Nitrofurantoin
Solubility
Time Factors
Chemical
Reg. No./Substance:
0/Capsules; 0/Excipients; 67-20-9/Nitrofurantoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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