Document Detail

Effect of sevoflurane concentration on inhalation induction of anaesthesia in the elderly.
MedLine Citation:
PMID:  10325830     Owner:  NLM     Status:  MEDLINE    
We have conducted a randomized, double-blind comparison of 4% and 8% sevoflurane for induction of anaesthesia in unpremedicated patients aged more than 60 yr. Sevoflurane was inhaled in 50% nitrous oxide using a vital capacity breath technique, and mean, systolic and diastolic arterial pressures and heart rate were monitored continuously using a Finapres cuff. In the 8% sevoflurane group, time to successful laryngeal mask insertion was significantly shorter (mean 168 (SD 34) s vs 226 (62) s; P < 0.01) and achieved more often at the first attempt than in the 4% sevoflurane group. Arterial pressures were lower in the 8% group, but this was not significant. No patient had apnoea lasting longer than 1 min. A total of 69% of patients described induction as pleasant and 85% would choose to have it again. We conclude that compared with 8% sevoflurane, the use of 4% sevoflurane in the elderly resulted in greater cardiovascular stability but at the cost of prolonged and occasionally unsuccessful induction.
R Walpole; M Logan
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  82     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-05-20     Completed Date:  1999-05-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  20-4     Citation Subset:  IM    
Western General Hospital, Edinburgh, UK.
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MeSH Terms
Aged, 80 and over
Anesthesia, Inhalation / methods
Anesthetics, Inhalation / administration & dosage*,  pharmacology
Blood Pressure / drug effects
Dose-Response Relationship, Drug
Double-Blind Method
Heart Rate / drug effects
Methyl Ethers / administration & dosage*,  pharmacology
Middle Aged
Patient Satisfaction
Time Factors
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Methyl Ethers; 28523-86-6/sevoflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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