| Effect of sevoflurane concentration on inhalation induction of anaesthesia in the elderly. | |
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MedLine Citation:
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PMID: 10325830 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have conducted a randomized, double-blind comparison of 4% and 8% sevoflurane for induction of anaesthesia in unpremedicated patients aged more than 60 yr. Sevoflurane was inhaled in 50% nitrous oxide using a vital capacity breath technique, and mean, systolic and diastolic arterial pressures and heart rate were monitored continuously using a Finapres cuff. In the 8% sevoflurane group, time to successful laryngeal mask insertion was significantly shorter (mean 168 (SD 34) s vs 226 (62) s; P < 0.01) and achieved more often at the first attempt than in the 4% sevoflurane group. Arterial pressures were lower in the 8% group, but this was not significant. No patient had apnoea lasting longer than 1 min. A total of 69% of patients described induction as pleasant and 85% would choose to have it again. We conclude that compared with 8% sevoflurane, the use of 4% sevoflurane in the elderly resulted in greater cardiovascular stability but at the cost of prolonged and occasionally unsuccessful induction. |
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Authors:
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R Walpole; M Logan |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: British journal of anaesthesia Volume: 82 ISSN: 0007-0912 ISO Abbreviation: Br J Anaesth Publication Date: 1999 Jan |
Date Detail:
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Created Date: 1999-05-20 Completed Date: 1999-05-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 20-4 Citation Subset: IM |
Affiliation:
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Western General Hospital, Edinburgh, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Anesthesia, Inhalation / methods Anesthetics, Inhalation / administration & dosage*, pharmacology Blood Pressure / drug effects Dose-Response Relationship, Drug Double-Blind Method Female Heart Rate / drug effects Humans Male Methyl Ethers / administration & dosage*, pharmacology Middle Aged Patient Satisfaction Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 0/Methyl Ethers; 28523-86-6/sevoflurane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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