Document Detail

Effect of sevoflurane anaesthesia on plasma concentrations of glutathione S-transferase.
MedLine Citation:
PMID:  8949820     Owner:  NLM     Status:  MEDLINE    
To assess the effect of sevoflurane anaesthesia on hepatocellular integrity, we measured plasma concentrations of glutathione S-transferase (GST) before anaesthesia and 1, 3, 6 and 24 h after the end of anaesthesia in 41 healthy, Japanese patients undergoing elective, body surface surgery. Sevoflurane (approximately 1.0 MAC) was delivered in 50-66% nitrous oxide in oxygen via a circle system, with a fresh gas flow of 6 litre min-1. Ventilation was spontaneous in all patients. Mean duration of anaesthesia was 101 min. Concentrations of GST increased significantly 1 h after the end of anaesthesia (P = 0.0075), but this was not significantly different from preoperative concentrations at 3, 6 and 24 h. Three patients developed a large secondary increase in GST concentrations at 24 h. The increase observed at 1 h was probably a result of reduced total liver blood flow; the mechanism for the secondary increase at 24 h is unclear but the possibility that products of sevoflurane biotransformation are responsible cannot be excluded.
D C Ray; R Bomont; A Mizushima; T Kugimiya; A Forbes Howie; G J Beckett
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  77     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1997-01-07     Completed Date:  1997-01-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  404-7     Citation Subset:  IM    
Department of Anaesthetics, Royal Infirmary, Edinburgh.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anesthetics, Inhalation / pharmacology*
Biological Markers / blood
Ethers / pharmacology*
Glutathione Transferase / blood*
Liver / drug effects*,  enzymology
Methyl Ethers*
Middle Aged
Postoperative Period
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Biological Markers; 0/Ethers; 0/Methyl Ethers; 28523-86-6/sevoflurane; EC Transferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of fentanyl, nitrous oxide, or both, on baroreceptor reflex regulation in the cat.
Next Document:  Normovolaemic haemodilution attenuates cardiac depression induced by sodium bicarbonate in canine me...