Document Detail

Effect of sevoflurane on P50 and on measurement of oxygen tension.
MedLine Citation:
PMID:  3142969     Owner:  NLM     Status:  MEDLINE    
Fresh samples of heparinized human blood from 10 healthy nonsmoking volunteers were used to study the effect of the inhaled anesthetic sevoflurane on the oxygen half-saturation pressure of hemoglobin (P50) and on polarographic measurements of oxygen tension at low values. Control samples had a baseline P50 of 26.9 +/- 0.2 mm Hg. When the blood samples were exposed to 1.75% (1 minimum alveolar concentration, MAC), 2.75%, and 3.5% (2 MAC) of sevoflurane, the P50 values were 27.0 +/- 0.5 mm Hg, 27.1 +/- 0.4 mm Hg, and 26.9 +/- 0.5 mm Hg, respectively. Our present data show that 1 to 2 MAC sevoflurane has no significant effect on P50 (P greater than 0.05). Our data also show that sevoflurane did not interfere with polarographic measurements of oxygen tension (P greater than 0.05). Other inhaled agents--halothane, enflurane, and isoflurane--do interfere with these measurements, and we cannot explain the difference.
J R Kambam; B F Horton; W C Parris; D A Holaday
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Journal of clinical monitoring     Volume:  4     ISSN:  0748-1977     ISO Abbreviation:  J Clin Monit     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1988-12-28     Completed Date:  1988-12-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8506707     Medline TA:  J Clin Monit     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  261-3     Citation Subset:  IM    
Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232.
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MeSH Terms
Anesthesia, Inhalation*
Carbon Dioxide / blood
Dose-Response Relationship, Drug
Ethers / administration & dosage,  pharmacology*
Hemoglobins / analysis*
Methyl Ethers*
Oxygen / blood*
Reg. No./Substance:
0/Ethers; 0/Hemoglobins; 0/Methyl Ethers; 124-38-9/Carbon Dioxide; 28523-86-6/sevoflurane; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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