| Effect of serum separator blood collection tubes on drug concentrations. | |
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MedLine Citation:
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PMID: 6356497 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Using the EMIT assay, we tested clinical samples from patients receiving 12 commonly monitored drugs to evaluate the effect of serum separator gel contained in serum separator blood collection tubes (SST) (Becton-Dickinson). There were significant concentration decreases for lidocaine, pentobarbital, and phenytoin. In vitro experiments demonstrated that this effect on phenytoin was dependent on time of exposure to the gel and volume of whole blood, but was not dependent on the presence of red blood cells or initial concentration. Bias attributed to the use of SST could interfere with the usefulness of clinical results at the upper and lower limits of the therapeutic range. This problem can be minimized by processing samples of at least 2 ml within 1 h. |
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Authors:
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F Quattrocchi; H T Karnes; J D Robinson; L Hendeles |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Therapeutic drug monitoring Volume: 5 ISSN: 0163-4356 ISO Abbreviation: Ther Drug Monit Publication Date: 1983 |
Date Detail:
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Created Date: 1983-12-20 Completed Date: 1983-12-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7909660 Medline TA: Ther Drug Monit Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 359-62 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Specimen Collection
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instrumentation* Drug Therapy Gels Humans Immunoenzyme Techniques Kinetics Pharmaceutical Preparations / blood* |
| Chemical | |
Reg. No./Substance:
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0/Gels; 0/Pharmaceutical Preparations |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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