Document Detail


Effect of serum from different patient populations on the serum bactericidal test.
MedLine Citation:
PMID:  11533009     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We evaluated the effect of serum from normal and uraemic volunteers, neutropenic patients and burn patients on the serum bactericidal test. Serum samples were spiked with ceftazidime to mimic in vivo peak (75 mg/L) and trough (5 mg/L) concentrations. Serum inhibitory and bactericidal titres (SIT and SBT) were performed in triplicate using Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853. For E. coli, the trough SIT and SBT were significantly higher in serum from burn patients compared with normal volunteers (P < or = 0.024). The trough SIT was significantly higher in serum from burn patients compared with neutropenic patients (P = 0.022) and in uraemic patients compared with normal volunteers (P = 0.04). No significant differences between subject populations were found for P. aeruginosa.
Authors:
M B Kays; R L White; L V Friedrich
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of antimicrobial chemotherapy     Volume:  48     ISSN:  0305-7453     ISO Abbreviation:  J. Antimicrob. Chemother.     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-09-04     Completed Date:  2001-12-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7513617     Medline TA:  J Antimicrob Chemother     Country:  England    
Other Details:
Languages:  eng     Pagination:  417-20     Citation Subset:  IM    
Affiliation:
Department of Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, Purdue University, Indianapolis, IN 46202-2879, USA. mkays@iupui.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Burns / blood
Ceftazidime / blood,  pharmacology*
Cephalosporins / blood,  pharmacology*
Escherichia coli / drug effects*
Female
Humans
Male
Microbial Sensitivity Tests
Middle Aged
Neutropenia / blood
Pseudomonas aeruginosa / drug effects*
Serum Bactericidal Test*
Uremia / blood
Chemical
Reg. No./Substance:
0/Cephalosporins; 78439-06-2/Ceftazidime

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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