| Effect of serotonin on pentagastrin-stimulated gastric acid secretion and gastric antral motility in dogs with gastric fistula. | |
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MedLine Citation:
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PMID: 3003884 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of exogenous serotonin on pentagastrin-stimulated gastric acid secretion and antral motility were evaluated with regard to inhibition kinetics and receptor mediation. Conscious gastric fistula dogs were used. Serotonin inhibited the acid secretion dose-dependently, whereas the antral motility was initially stimulated and thereafter inhibited. The inhibition of secretion was counteracted by different beta-adrenergic blocking drugs and methysergide, whereas the inhibition of antral motility was blocked by methysergide and indomethacin. Dose-response analysis showed inhibition of non-competitive types. This study supports the concept of differences in the regulation of gastric acid secretion and motility, but further experiments with simultaneous registration are required. |
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Authors:
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K Bech; D Andersen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Scandinavian journal of gastroenterology Volume: 20 ISSN: 0036-5521 ISO Abbreviation: Scand. J. Gastroenterol. Publication Date: 1985 Nov |
Date Detail:
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Created Date: 1986-03-12 Completed Date: 1986-03-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0060105 Medline TA: Scand J Gastroenterol Country: NORWAY |
Other Details:
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Languages: eng Pagination: 1115-23 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dogs Dose-Response Relationship, Drug Female Gastric Acid / secretion* Gastric Fistula / physiopathology* Gastrointestinal Motility / drug effects* Kinetics Male Pentagastrin / pharmacology* Pyloric Antrum / drug effects* Receptors, Adrenergic, beta / drug effects Receptors, Dopamine / drug effects Receptors, Serotonin / drug effects Serotonin / metabolism, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Adrenergic, beta; 0/Receptors, Dopamine; 0/Receptors, Serotonin; 50-67-9/Serotonin; 5534-95-2/Pentagastrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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